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The mammalian protein disulphide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulphide bonds. PDI, an abundant protein of the ER (>400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing – and one domain lacking – a redox-active-Cys-X-X-Cys-tetrapeptide. In addition to roles as redox catalysts and isomerases, PDI proteins perform such functions as peptide binding and cell adhesion, and may conduct chaperone activities. Platelet surface thiols and disulphides play an important role in platelet responses. Catalytically active PDI resides on platelet surfaces where it mediates platelet aggregation and secretion by reducing disulfide bonds, thus exposing fibrinogen receptors in platelets.
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Immunohistochemistry analysis of human HEK293 cells transfected with wild type TorsinA co-stained with PDI mAb (1D3) (red). Co-localization of TorsinA and PDI proteins merge as yellow.
Western blot analysis of PDI: Lane 1: MW marker, Lane 2: HeLa (HS) Lane 3: ADI-SPP-891, Lane 4: Vero (HS), Lane 5: 3T3 (HS), Lane 6: PC-12 (HS), Lane 7: CHO-K1 (HS)
USP13 loss-of-function causes TCRα to accumulate in aggregates in cells.(A) Cells co-expressing TCRα-YFP together with the indicated shRNAs were subject to sequential extraction, first by an NP40-containing lysis buffer, then by the Laemmli buffer. The NP40 soluble (S) and insoluble (P) fractions were analyzed by immunoblotting. UBE1 and H2A serve as markers for the NP40 soluble (S) and insoluble (P) fractions, respectively. (B) Expression of USP13 inhibits TCRα degradation in a dominant negative manner. COS7 cells transfected with TCRα-YFP together with either control or the indicated USP13-expressing constructs were stained by a PDI antibody in red. Cells were imaged using a Zeiss Axiovert fluorescence microscope with the exposure time set to auto. Note that in USP13 and USP13 C345S transfected cells, TCRα-YFP often accumulates in aggregates that are not localized to the same focal plane as the ER marker PDI. Scale bars, 10 µm. (C) USP13 knockdown stabilizes an ERAD substrate in both glycosylated and deglycosylated forms. Cells co-expressing TCRα-ΔTMD together with the indicated shRNAs were subject to sequential extraction, first by an NP40-containing lysis buffer, then by the Laemmli buffer. Where indicated, the extracts were treated with EndoH before immunoblotting.DOI:http://dx.doi.org/10.7554/eLife.01369.008
Image collected and cropped by CiteAb under a CC0-1.0 license from the following publication: USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation. Elife (2014)
Product Details
| Alternative Name |
P4HB, protein disulfide isomerase |
|---|---|
| Application |
Electron microscopy, ICC, IF, IHC, WB |
| Application Notes |
Detects a band of ~58kDa by Western blot. |
| Clone |
1D3 |
| Formulation |
Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
| Host |
Mouse |
| Immunogen |
Synthetic peptide corresponding to the sequence near the C-terminus of rat PDI. |
| Isotype |
IgG1 |
| Purity Detail |
Protein G affinity purified. |
| Recommendation Dilutions/Conditions |
Immunohistochemistry (1:200-1:500)Western Blot (1:1,000, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Source |
Purified from ascites |
| Species Reactivity |
Bovine, Chicken, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep, Xenopus |
| Technical Info / Product Notes |
Cited samples: |
| UniProt ID |
P04785 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Handling |
Avoid freeze/thaw cycles. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Characterization of a Novel Col1a1G643S/+ Osteogenesis Imperfecta Mouse Model with Insights into Skeletal Phenotype, Fragility, and Therapeutic Evaluations: Saitou, H., Ohata, Y., et al.; Calcif. Tissue Int. 116, 13 (2025), Abstract
- ADrosophilamodel for Dent’s disease reveals impaired ER export of Cubilin as pathogenic mechanism: Christer, S., Marelja, Z., et al.; bioRxiv , (2025)
- Neuronal CD59 isoforms IRIS-1 and IRIS-2 as regulators of neurotransmitter release with implications for Alzheimer’s disease: Golec, E., Olsson, R., et al.; Alzheimers Res. Ther. 17, 11 (2025), Application(s): Western blot, Abstract
- Redox signaling-mediated S-glutathionylation of protein disulfide isomerase A1 initiates intrinsic apoptosis and contributes to accelerated aging: Ye, Z. W., Zhang, J., et al.; Redox Biol. 85, 103680 (2025), Application(s): Immunofluorescence, Abstract
- The Role of Estrogen and ER Stress in Glycemic Regulation in the Sexually Dimorphic TALLYHO/JngJ Mouse Model of Diabetes: De Paoli, M., Patel, Z., et al.; J. Endocr. Soc. 9, bvaf048 (2025), Abstract
- Legionella effector LpPIP recruits protein phosphatase 1 to the mitochondria to induce dephosphorylation of outer membrane proteins: Yek, K. Q., Hodgson, E. R., et al.; PLoS Biol. 23, e3003261 (2025), Abstract
- TUG protein acts through a disordered region to organize the early secretory pathway: Parchure, A., Tejada, H., et al.; Nat. Commun. 16, 5518 (2025), Abstract
- Cytoarchitecture of ex vivo midgut cultures of unfed Ixodes scapularis infected with a tick-borne flavivirus: M. Ochwoto, et al.; Ticks Tick Borne Dis. 15, 102301 (2024), Abstract
- Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells.: De Paoli, M., Shah, D., et al.; Int. J. Mol. Sci. 25, (2024), Reactant(s): Mouse, Abstract
- Perturbation ofde novolipogenesis hinders MERS-CoV assembly and release, but not the biogenesis of viral replication organelles: Soultsioti, M., de Jong, A., et al.; bioRxiv , (2024), Reactant(s): Human
- Colocalization by cross-correlation, a new method of colocalization suited for super-resolution microscopy: A.D. McCall; BMC Bioinformatics 25, 55 (2024), Abstract
- Cx31.1 can selectively intermix with co-expressed connexins to facilitate its assembly into gap junctions: Leighton, S. E., Wong, R. S., et al.; J. Cell Sci. 137, (2024), Abstract
- Novel Pannexin 1 isoform is increased in cancer: O’Donnell, B. L., Stefan, D., et al.; bioRxiv , (2024)
- The Zn2+ transporter ZIP7 enhances endoplasmic-reticulum-associated protein degradation and prevents neurodegeneration in Drosophila: Guo, X., Mutch, M., et al.; Dev. Cell 59, 1655 (2024), Abstract
- CD59 double knockout mice express a CD59ba hybrid fusion protein that mediates insulin secretion: A. Ekström, et al.; FASEB J. 38, e70156 (2024), Abstract
- African swine fever virus transmembrane protein pEP84R guides core assembly: A. Alejo, et al.; PLoS Pathog. 19, e1011136 (2023), Abstract
- NecroX improves PHMG-induced lung injury by regulating mitochondrial oxidative stress and ER stress: J.S. Jeong, et al.; Am. J. Respir. Cell Mol. Biol. 69, 57 (2023), Abstract
- Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts: P.Y. Ng, et al.; Nat. Commun. 14, 906 (2023), Abstract
- Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex.: Franzka, P., Schüler, S. C., et al.; Biomedicines 11, (2023), Application(s): ICC, WB / Reactant(s): Mouse, Abstract
- Overexpression of a Novel Noxo1 Mutant Increases Ros Production and Noxo1 Relocalisation.: Benssouina, F. Z., Parat, F., et al.; Int. J. Mol. Sci. 24, (2023), Reactant(s): Human, Abstract
- GJB4 variants linked to skin disease exhibit a trafficking deficiency en route to gap junction formation that can be restored by co-expression of select connexins: Lucaciu, S. A., Figliuzzi, R., et al.; Front Cell Dev Biol 11, 1073805 (2023), Application(s): ICC-IF, Abstract
- Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins: Page, K. R., Nguyen, V. N., et al.; bioRxiv , (2023)
- SARS-CoV-2 ORF3A interacts with the Clic-like chloride channel-1 (CLCC1) and triggers an unfolded protein response: Gruner, H. N., Zhang, Y., et al.; PeerJ 11, e15077 (2023), Abstract
- Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers: Wu, S., Hernandez Villegas, N. C., et al.; Elife 12, (2023), Abstract
- Vimentin intermediate filaments provide structural stability to the mammalian Golgi complex: Vitali, T., Sánchez-Alvarez, R., et al.; J. Cell Sci. 136, (2023), Abstract
- An AMPKα2-specific phospho-switch controls lysosomal targeting for activation: K.R. Morrison, et al.; Cell Rep. 38, 113065 (2022), Abstract
- Functional Assessment of Calcium-Sensing Receptor Variants Confirms Familial Hypocalciuric Hypercalcemia: B.H. Mullin, et al.; J. Endocr. Soc. 6, bvac025 (2022), Abstract
- Tissue Transglutaminase but Not Microbial Transglutaminase Is Inhibited by Exogenous Oxidative Substances in Celiac Disease: S. Stricker, et al.; Int. J. Mol. Sci. 23, 2248 (2022), Abstract
- Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS: Y. Shinohara, et al.; Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1867, 159136 (2022), Abstract
- DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy: D. Imberechts, et al.; Brain 145, 4368 (2022), Abstract
- Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma: E. Fiorito, et al.; Br. J. Cancer 127, 1939 (2022), Abstract
- Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development: C. Bollmann, et al.; Neural Dev. 17, 12 (2022), Abstract
- Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.: Lu, C. L., Ortmeier, S., et al.; Traffic 23, 81 (2022), Application(s): ICC-IF, WB / Reactant(s): Mouse, Abstract
- IBF-R Regulates IRE1α Post-Translational Modifications and ER Stress in High-Fat Diet-Induced Obese Mice.: Chae, H. J., Yoon, Y., et al.; Nutrients 14, (2022), Reactant(s): Mouse, Abstract
- A homozygous hypomorphic BNIP1 variant causes an increase in autophagosomes and reduced autophagic flux and results in a spondylo-epiphyseal dysplasia.: Holling, T., Bhavani, G. S., et al.; Hum. Mutat. 43, 625 (2022), Application(s): IF, Abstract
- Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1G93A mouse model of amyotrophic lateral sclerosis.: Salvany, S., Casanovas, A., et al.; Brain Pathol. 32, e13078 (2022), Reactant(s): Mouse, Abstract
- Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function: Arotcarena, M. L., Soria, F. N., et al.; Aging Cell 21, e13584 (2022), Abstract
- AGAL misprocessing-induced ER stress and the unfolded protein response: lysosomal storage-independent mechanism of Fabry disease pathogenesis?: Zivná, M., Dostalova, G., et al.; bioRxiv , (2022)
- CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival: Eesmaa, A., Yu, L. Y., et al.; Int. J. Mol. Sci. 23, (2022), Abstract
- Interrogation of Carboxy-Terminus Localized GJA1 Variants Associated with Erythrokeratodermia Variabilis et Progressiva: Lucaciu, S. A., Shao, Q., et al.; Int. J. Mol. Sci. 23, (2022), Abstract
- Vimentin intermediate filaments provide structural stability to the mammalian Golgi apparatus: Vitali, T., Witkos, T. M., et al.; bioRxiv , (2022)
- Plasma biomarkers for prediction of early tumor recurrence after resection of pancreatic ductal adenocarcinoma: M.C. Rittmann, et al.; Sci. Rep. 11, 7499 (2021), Abstract — Full Text
- MICAL-L1 is required for cargo protein delivery to the cell surface: R. Sikora, et al.; Biol. Open 10, bio058008 (2021), Abstract — Full Text
- Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites.: Mathews, E. S., Jezewski, A. J., et al.; Mbio 12, e0076021 (2021), Application(s): IHC-IF, Abstract
- TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans.: Chae, H. J., Kim, H. R., et al.; Redox Biol. 47, 102128 (2021), Application(s): WB, Abstract
- A Yellow Fever 17D Virus Replicon-Based Vaccine Platform for Emerging Coronaviruses.: Oreshkova, N., Myeni, S. K., et al.; Vaccines (Basel) 9, (2021), Application(s): ICC-IF / Reactant(s): Hamster, Abstract
- Collective border cell migration requires the zinc transporter Catsup to limit endoplasmic reticulum stress: Dai, W., Montell, D., et al.; bioRxiv , (2021), Reactant(s): Drosophila melanogaster
- A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization: Okumura, M., Kanemura, S., et al.; Structure 29, 1357 (2021), Abstract
- Acitretin and Retinoic Acid Derivatives Inhibit BK Polyomavirus Replication in Primary Human Proximal Renal Tubular Epithelial and Urothelial Cells: Wu, Z., Graf, F. E., et al.; J. Virol. 95, e0012721 (2021), Abstract
- Advanced Microscopy for Liver and Gut Ultrastructural Pathology in Patients with MVID and PFIC Caused by MYO5B Mutations: Hess, M. W., Krainer, I. M., et al.; J. Clin. Med. 10, (2021), Abstract
- Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum: Lu, C., Ortmeier, S., et al.; bioRxiv , (2021)
- Characterization of the complex of the lysosomal membrane transporter MFSD1 and its accessory subunit GLMP: D. Lopez, et al.; FASEB J. 34, 14695 (2020), Abstract
- The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation: R.C. Henrici, et al.; Mbio 11, e02918-19 (2020), Abstract — Full Text
- The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of the Postsynaptic Compartment of C-Type Cholinergic Afferent Synapses on Motoneurons: A. Gatius, et al.; Front. Cell. Neurosci. 13, 582 (2020), Application(s): ICC, Abstract — Full Text
- Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.: Yang, J., Gnädig, N. F., et al.; Nat. Commun. 11, 1780 (2020), Application(s): ICC-IF, Abstract
- Molecular mechanisms that regulate export of the planar cell-polarity protein Frizzled-6 out of the endoplasmic reticulum.: Tang, X., Zhang, L., et al.; J. Biol. Chem. 295, 8972 (2020), Application(s): ICC-IF, IF, Abstract
- 4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts.: Ozono, K., Kitaoka, T., et al.; J. Biol. Chem. 296, 100027 (2020), Application(s): ICC-IF / Reactant(s): Human, Abstract
- MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α: Saarma, M., Lindholm, P., et al.; bioRxiv , (2020), Application(s): ICC / Reactant(s): Human
- A unique adhesive motif of protein disulfide isomerase P5 supports its function via dimerization: Okumura, M., Kanemura, S., et al.; bioRxiv , (2020)
- MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B: Cinque, L., De Leonibus, C., et al.; EMBO J. 39, e105696 (2020), Abstract
- The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole: G. Arango Duque, et al.; PLoS Pathog. 15, e1007982 (2019), Abstract — Full Text
- A critical role of VMP1 in lipoprotein secretion: H. Morishita, et al.; Elife 8, e48834 (2019), Application(s): WB, Abstract — Full Text
- Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease: V. Granatiero, et al.; Life Sci. Alliance 2, e201900563 (2019), Abstract — Full Text
- DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans: G. Karsai, et al.; J. Clin. Invest. 129, 1229 (2019), Abstract
- TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle: J. Geng, et al.; FASEB J. 33, 6082 (2019), Abstract
- Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy: E. Galli, et al.; Cell Transplant. 6, 963689719827943 (2019), Abstract — Full Text
- Zinc regulates ERp44-dependent protein quality control in the early secretory pathway: S. Watanabe, et al.; Nat. Commun. 10, 603 (2019), Application(s): WB + IF, Abstract — Full Text
- FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function.: Wang, L., Yan, Z., et al.; J. Cell Biol. 218, 97 (2019), Application(s): WB / Reactant(s): Human, Mouse, Abstract
- Syzygium cumini Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats.: França, L. M., Coêlho, C. F. F., et al.; Oxid. Med. Cell. Longev. 2019, 9417498 (2019), Application(s): WB / Reactant(s): Rat, Abstract
- A BRET-based assay reveals collagen-Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction.: Nagata, K., Takeuchi, K., et al.; J. Biol. Chem. 294, 15962 (2019), Application(s): ICC-IF, IF / Reactant(s): Human, Abstract
- TMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities.: van der Spek, P. J., Kayserili, H., et al.; Am. J. Hum. Genet. 105, 1126 (2019), Reactant(s): Human, Abstract
- Localization of immunoreactive, dystonia-associated protein torsinA near the Golgi apparatus of cultured rodent astrocytes: Iwabuchi, S., Kawano, H., et al.; bioRxiv , (2019), Application(s): ICC
- Localization of the signal of dystonia-associated protein torsinA near the Golgi apparatus in cultured central neurons: Iwabuchi, S., Kawano, H., et al.; bioRxiv , (2019), Application(s): ICC
- HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways: Park, A., Ra, E. A., et al.; Nat. Commun. 10, 4670 (2019), Abstract
- Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A: Marchesin, V., Pérez-Martí, A., et al.; Cell Rep. 29, 4407 (2019), Abstract
- Pan-active imidazolopiperazine antimalarials target the i>Plasmodium falciparum/i> intracellular secretory pathway: LaMonte, G. M., Marapana, D. S., et al.; bioRxiv , (2019)
- Protein prenylation and Hsp40 in thermotolerance ofi>Plasmodium falciparum/i>malaria parasites: Mathews, E. S., Jezewski, A. J., et al.; bioRxiv , (2019)
- Recombinant Hepatitis E Viruses Harboring Tags in the ORF1 Protein: Szkolnicka, D., Pollán, A., et al.; J. Virol. 93, (2019), Abstract
- Modifications of the 26S proteasome during boar sperm capacitation: M. Zigo, et al.; Cell Tissue Res. 372, 591 (2018), Abstract
- A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex: A. Forrester, et al.; EMBO J. 2018, e99847 (2018), Application(s): WB / Reactant(s) Human, Abstract
- Cyt/Nuc,” a Customizable and Documenting ImageJ Macro for Evaluation of Protein Distributions Between Cytosol and Nucleus”””: T. Grune, et al.; Biotechnol J. 13, 1700652 (2018), Abstract
- Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses: H.J. Choi, et al.; Nat. Commun. 9, 125 (2018), Application(s): ICC-IF, Abstract — Full Text
- Substitutions for arginine at position 780 in triple helical domain of the α1(I) chain alter folding of the type I procollagen molecule and cause osteogenesis imperfecta: E. Makareeva, et al.; PLoS One 13, e0200264 (2018), Application(s): WB / Reactant(s) Human, Abstract — Full Text
- Targeting of severe fever with thrombocytopenia syndrome virus structural proteins to the ERGIC (endoplasmic reticulum Golgi intermediate compartment) and Golgi complex: T. Lundu, et al.; Biomed. Res. 39, 27 (2018), Abstract — Full Text
- N-Glycosylation Regulates Pannexin 2 Localization but Is Not Required for Interacting with Pannexin 1.: Sanchez-Pupo, R. E., Johnston, D., et al.; Int. J. Mol. Sci. 19, (2018), Application(s): ICC-IF, IF, Abstract
- Aberrant DEGS1 sphingolipid metabolism impairs central and peripheral nervous system function in humans: Weis, J., Elbracht, M., et al.; bioRxiv , (2018), Application(s): IHC / Reactant(s): Human
- The unique nested genei>ALZAS/i>as a potential source of Aβ-peptides in Alzheimer’s disease: Reichmann, H., Janetzky, B., et al.; bioRxiv , (2018), Application(s): ICC / Reactant(s): Human
- Parallel genome-wide CRISPR analysis identifies a role for heterotypic ubiquitin chains in ER-associated degradation: Leto, D. E., Morgens, D. W., et al.; bioRxiv , (2018)
- PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD-RIG-I-NF-κB axis: Kim, H. K., Lee, G. H., et al.; Exp. Mol. Med. 50, e444 (2018), Abstract
- Label-free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines: B. Prats Mateu, et al.; Biotechnol J. 12, 1600037 (2017), Application(s): IF on CHO cells, Abstract
- Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination: E. Seemann, et al.; Elife 6, e29854 (2017), Abstract — Full Text
- Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE: L.F. Zacchi, et al.; Dis. Model. Mech. 10, 1129 (2017), Application(s): WB, Abstract — Full Text
- Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress: J. Sieber, et al.; J. Biol. Chem. 292, 18878 (2017), Abstract — Full Text
- Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis: I.Y. Kim, et al.; Oncotarget 8, 106740 (2017), Application(s): Western Blot, Abstract — Full Text
- ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2.: Kee, A. J., Bryce, N. S., et al.; Cytoskeleton (Hoboken) 74, 379 (2017), Application(s): ICC-IF / Reactant(s): Mouse, Abstract
- Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase: H. Kenche, et al.; J. Biol. Chem. 291, 4763 (2016), Application(s): Western blot and IHC on human tissue, Abstract — Full Text
- Diagnostic Exome Sequencing Identifies a Novel Gene, EMILIN1, Associated with Autosomal-Dominant Hereditary Connective Tissue Disease: A. Capuano, et al.; Hum. Mutat. 37, 84 (2016), Application(s): IF / Reactant(s) Mouse, Abstract — Full Text
- Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain: P. Grigaravicius, et al.; Cell Death Differ. 23, 454 (2016), Abstract — Full Text
- COMP-assisted collagen secretion–a novel intracellular function required for fibrosis: J.N. Schulz, et al.; J. Cell Sci. 129, 706 (2016), Application(s): immunofluorescence staining of collagen I and collagen XII, Abstract — Full Text
- Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia: N.A. Bolar, et al.; Am. J. Hum. Genet. 99, 174 (2016), Application(s): Intracellular localization of SEC61A1 in endoplasmic reticulum, Abstract
- Hints to the diagnosis of uromodulin kidney disease: T. Onoe, et al.; Clin. Kidney J. 9, 69 (2016), Application(s): Immunostaining of Tamm-Horsfall protein, Abstract — Full Text
- Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains: Schrul, B., Kopito, R. R., et al.; Nat. Cell Biol. 18, 740 (2016), Abstract
- Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR: Colombo, S. F., Cardani, S., et al.; J. Biol. Chem. 291, 15292 (2016), Abstract
- Cx30 exhibits unique characteristics including a long half-life when assembled into gap junctions: J.J. Kelly, et al.; J. Cell Sci. 128, 3947 (2015), Application(s): IF / Reactant(s) Rat, Abstract
- The Golgi apparatus regulates cGMP-dependent protein kinase I compartmentation and proteolysis: S. Kato, et al.; Am. J. Physiol. Cell Physiol. 308, C944 (2015), Abstract — Full Text
- Topology of Endoplasmic Reticulum-Associated Cellular and Viral Proteins Determined with Split-GFP: S.I. Hyun, et al.; Traffic 16, 787 (2015), Abstract
- Human Cytomegalovirus Up-Regulates Endothelin Receptor Type B: Implication for Vasculopathies?: K.C. Yaiw, et al.; Open Forum Infect. Dis. 2, ofv155 (2015), Application(s): Immunofluorescence, Abstract — Full Text
- Comparative proteomic analysis of compartmentalised Ras signalling: M. Hernandez-Valladares, et al.; Sci. Rep. 5, 17307 (2015), Application(s): Colocalization studies, Abstract — Full Text
- ISG15 counteracts Listeria monocytogenes infection: L. Radoshevich, et al.; eLife 4, e06848 (2015), Application(s): Cell culture, Abstract
- Orotate phosphoribosyltransferase localizes to the Golgi complex and its expression levels affect the sensitivity to anti-cancer drug 5-fluorouracil: Y. Hozumi, et al.; Biomed. Res. 36, 403 (2015), Application(s): Immunocytochemistry, Abstract — Full Text
- Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure: H. Kentala, et al.; Steroids 99, 248 (2015), Application(s): Staining, Abstract
- Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum: E. Avezov, et al.; BMC Biol 13, 2 (2015), Application(s): Western Blotting, Abstract — Full Text
- Legionella suppresses the host unfolded protein response via multiple mechanisms.: Mukherjee, S., Treacy-Abarca, S., et al.; Nat. Commun. 6, 7887 (2015), Application(s): WB / Reactant(s): Human, Mouse, Abstract
- Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.: Arumäe, U., Saarma, M., et al.; Cell Death Dis. 6, e2032 (2015), Application(s): ICC, Abstract
- Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3: U. Kornak, et al.; Brain 137, 683 (2014), Abstract
- Neuregulin-1 is concentrated in the postsynaptic subsurface cistern of C-bouton inputs to a-motoneurons and altered during motoneuron diseases: X. Gallart-Palau, et al.; FASEB J. 28, 3618 (2014), Abstract
- Antibodies That Detect O-Linked β-D-N-Acetylglucosamine on the Extracellular Domain of Cell Surface Glycoproteins: Y. Tashima, et al.; J. Biol. Chem. 289, 11132 (2014), Abstract
- Calreticulin from suboolemmal vesicles affects membrane regulation of polyspermy: M.D. Saavedra, et al.; Reproduction 147, 369 (2014), Application(s): ICC-IF / Reactant(s) Pig, Abstract
- USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.: Liu, L., Lee, J. G., et al.; Elife 3, e01369 (2014), Application(s): ICC-IF, Abstract
- Deficiency of TDAG51 Protects Against Atherosclerosis by Modulating Apoptosis, Cholesterol Efflux, and Peroxiredoxin-1 Expression: G.S. Hossain, et al.; JAHA 2, e000134 (2013), Application(s): IHC using human carotid arteries, Abstract — Full Text
- Birbeck granule-like organized smooth endoplasmic reticulum resulting from the expression of a cytoplasmic YFP-tagged langerin: Lenormand, C., Spiegelhalter, C., et al.; PLoS One 8, e60813 (2013), Abstract
- Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase: Kenche, H., Baty, C. J., et al.; FASEB J. 27, 965 (2013), Abstract
- Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress: Takayanagi, S., Fukuda, R., et al.; Cell Stress Chaperones 18, 11 (2013), Abstract
- Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis: C.S. McAlpine, et al.; Arterioscler. Thromb. Vasc. Biol. 32, 82 (2012), Application(s): WB using mouse liver lysates, Abstract — Full Text
- Quantitative Proteomics Reveals That Only a Subset of the Endoplasmic Reticulum Contributes to the Phagosome: F.-X. Campbell-Valois, et al.; Mol. Cell. Proteomics 11, M111.016378 (2012), Application(s): WB using murine macrophage J774A.1 cells, Abstract — Full Text
- Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS: N. Bernard-Marissal, et al.; J. Neurosci. 32, 4901 (2012), Application(s): ICC using murine motorneurons, Abstract — Full Text
- Activation of the unfolded protein response by Listeria monocytogenes: Pillich, H., Loose, M., et al.; Cell. Microbiol. 14, 949 (2012), Abstract
- Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection: Stantchev, T. S., Paciga, M., et al.; Retrovirology 9, 97 (2012), Abstract
- The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load: K.-T. Chin, et al.; FASEB J. 25, 2583 (2011), Application(s): WB using mouse embryonic fibroblasts (MEF), Abstract — Full Text
- Hepatitis C Virus NS2 Protein Serves as a Scaffold for Virus Assembly by Interacting with both Structural and Nonstructural Proteins: Y. Ma, et al.; J. Virol. 85, 86 (2011), Application(s): ICC using human FT3-7 hepatoma cells, Abstract — Full Text
- The Antifungal Drug Itraconazole Inhibits Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, Trafficking, and Signaling in Endothelial Cells: B.A. Nacev, et al.; J. Biol. Chem. 286, 44045 (2011), Application(s): ICC using human vascular endothelial cells (HUVEC), Abstract — Full Text
- Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors: S. Dey & H. Matsunami; PNAS 108, 16651 (2011), Application(s): ICC using murine NIH/3T3 cells, Abstract — Full Text
- HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells: Leu, J. I., Pimkina, J., et al.; Mol. Cancer Res. 9, 936 (2011), Abstract
- Temperature-dependence of Weibel-Palade body exocytosis and cell surface dispersal of von Willebrand factor and its propolypeptide: Hewlett, L., Zupančič, G., et al.; PLoS One 6, e27314 (2011), Abstract
- Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution: A. Chadrin, et al.; J. Cell Biol. 189, 795 (2010), Application(s): Fluorescence microscopy, Abstract
- Airway Epithelial Inflammation-induced Endoplasmic Reticulum Ca(2+)Store Expansion Is Mediated by X-box Binding Protein-1: C. Ribeiro, et al.; J. Biol. Chem. 284, 14904 (2009), Application(s): WB using human tissue, Abstract
- Loss of Specific Chaperones Involved in Membrane Glycoprotein Biosynthesis during the Maturation of Human Erythroid Progenitor Cells: S.T. Patterson, et al.; J. Biol. Chem. 284, 14547 (2009), Application(s): WB using primary human erythroids, Abstract — Full Text
- Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death: T. Panaretakis, et al.; EMBO J. 28, 578 (2009), Application(s): WB using murine CT26 cells, Abstract — Full Text
- Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages: C.X.C. Santos, et al.; J. Leukoc. Biol. 86, 989 (2009), Application(s): WB and ICC using murine macrophage-like J774 cells, Abstract — Full Text
- A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes: W. Schwarzer, et al.; Hum. Mol. Genet. 18, 4013 (2009), Application(s): ICC using human Cos-1/HEK293 FlpIn T-Rex cells, Abstract — Full Text
- Reticulon-4A (Nogo-A) Redistributes Protein Disulfide Isomerase to Protect Mice from SOD1-Dependent Amyotrophic Lateral Sclerosis: Y.S. Yang, et al.; J. Neurosci. 29, 13850 (2009), Application(s): IHC using murine lumbar spinal cord samples, Abstract — Full Text
- Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans: C. Yun, et al.; PNAS 105, 7094 (2008), Application(s): ICC using monkey COS1 cells, Abstract — Full Text
- A Novel Actin-Related Protein Is Associated with Daughter Cell Formation in Toxoplasma gondii: J.L. Gordon , et al.; Eukaryot. Cell 7, 1500 (2008), Application(s): EM using parasite-infected human foreskin fibroblasts (HFF), Abstract — Full Text
- The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathway: E.A. Fisher, et al.; J. Lipid Res. 49, 2149 (2008), Application(s): WB using human HepG2 cells, Abstract — Full Text
- TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton: C. Flávia, et al.; J. Cell Sci. 121, 3476 (2008), Application(s): ICC using mouse embryonic fibroblasts (MEF), Abstract — Full Text
- Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes -Evidence for an autoregulatory mechanism: F. Rivero, et al.; Exp. Cell Res. 314, 3453 (2008), Application(s): ICC, IF using monkey tissue culture, Abstract
- Heterotypic tubular connections at the endoplasmic reticulum-Golgi complex interface: J. Martinez-Menarguez, et al.; Histochem. Cell Biol. 130, 709 (2008), Application(s): EM using rat tissue, Abstract
- Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis: D.B. Gould, et al.; Hum. Mol. Genet. 16, 798 (2007), Application(s): IHC using murine enucleated eyes, Abstract — Full Text
- Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction.: N. Wajih, et al.; J. Biol. Chem. 282, 2626 (2007), Application(s): WB using transfected hamster BHK-21 cells, Abstract — Full Text
- Missense Mutations in APOB within the beta{alpha}1 Domain of Human APOB-100 Result in Impaired Secretion of ApoB and ApoB-containing Lipoproteins in Familial Hypobetalipoproteinemia: J.R. Burnett, et al.; J. Biol. Chem. 282, 24270 (2007), Application(s): WB using transfected rat McA-RH7777 cells, Abstract — Full Text
- Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells: J.W. Hewett, et al.; PNAS 104, 7271 (2007), Application(s): ICC using human fibroblast cell lines, Abstract — Full Text
- Thromboxane hypersensitivity in hypoxic pulmonary artery myocytes: altered TP receptor localization and kinetics: S. Dakshinamurti, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 292, L654 (2007), Application(s): ICC using porcine tissue culture, Abstract
- Functions of ERp57 in the Folding and Assembly of Major Histocompatibility Complex Class I Molecules: Y. Zhang, et al.; J. Biol. Chem. 281, 14622 (2006), Application(s): FC using mouse L cells, Abstract — Full Text
- The cellular response to heat stress in the goby Gillichthys mirabilis: a cDNA microarray and protein-level analysis: B.A. Buckley, et al.; J. Exp. Biol. 209, 2660 (2006), Application(s): WB using fish (cooper) gill and white muscle tissue samples, Abstract — Full Text
- Changes of endoplasmic reticulum chaperone complexes, redox state, and impaired protein disulfide reductase activity in misfolding {alpha}1-antitrypsin transgenic mice: E. Papp, et al.; FASEB J. 20, 1018 (2006), Application(s): IP using murine liver microsomes, Abstract — Full Text
- Different MHC Class I Heavy Chains Compete with Each Other for Folding Independently of β2-Microglobulin and Peptide: S. Tourdot, et al.; J. Immunol. 174, 925 (2005), Application(s): ICC using transfected hamster CHO cells, Abstract — Full Text
- Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1: L. Mee, et al.; Hum. Mol. Genet. 14, 1475 (2005), Application(s): ICC using transfected monkey COS-1 cells, Abstract — Full Text
- Contribution of Cubilin and Amnionless to Processing and Membrane Targeting of Cubilin–Amnionless Complex: G. Coudroy, et al.; J. Am. Soc. Nephrol. 16, 2330 (2005), Application(s): ICC using canine MDCK cells, Abstract — Full Text
- Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex: D.R. Peaper, et al.; EMBO J. 24, 3613 (2005), Application(s): IP using human HeLa-M, FO-1, FO-1.b2m and CEM.NKR cells, Abstract — Full Text
- Misfolding of Major Histocompatibility Complex Class I Molecules in Activated T Cells Allows cis-Interactions with Receptors and Signaling Molecules and Is Associated with Tyrosine Phosphorylation: S.G. Santos, et al.; J. Biol. Chem. 279, 53062 (2004), Application(s): WB using human peripheral blood T lymphocytes (PBL), Abstract — Full Text
- Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles: M. Hsu , et al.; PNAS 100, 7271 (2003), Application(s): FC using human transfected 293-T cells, Abstract — Full Text
- Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction: A.J. Zhu, et al.; Genes & Dev. 17, 1240 (2003), Application(s): ICC using Drosophila salivary gland cells, Abstract — Full Text
- Chaperone action in the posttranslational topological reorientation of the hepatitis B virus large envelope protein: Implications for translocational regulation: C. Lambert & R. Prange; PNAS 100, 5199 (2003), Application(s): WB using transfected, immunoprecipitated monkey COS-7 cells, Abstract — Full Text
- Determinant for Endoplasmic Reticulum Retention in the Luminal Domain of the Human Cytomegalovirus US3 Glycoprotein: S. Lee, et al.; J. Virol. 77, 2147 (2003), Application(s): ICC using human HtTa cells, Abstract — Full Text
- Differential interaction of molecular chaperones with procollagen I and type IV collagen in corneal endothelial cells: E.P. Kay, et al.; Mol. Vis. 8, 9 (2002), Application(s): WB using rabbit samples, Abstract
- Activation of myosin V-based motility and F-actin-dependent network formation of endoplasmic reticulum during mitosis: S.A. Kuznetsov, et al.; J. Cell Biol. 159, 571 (2002), Application(s): ICC using xenopus samples, Abstract
- TorsinA immunoreactivity in brains of patients with DYT1 and non-DYT1 dystonia: P. Shashidharan, et al.; Neurology 58, 120 (2002), Application(s): IHC using human samples, Abstract
- Kinectin is a key effector of RhoG microtubule-dependent cellular activity: P. Fort, et al.; Mol. Cell. Biol. 21, 8022 (2001), Application(s): ICC using monkey & rat samples, Abstract
- Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man: T.J. Jentsch, et al.; Cell 104, 205 (2001), Application(s): IHC using mouse samples, Abstract
- A 56-kDa Selenium-binding Protein Participates in Intra-Golgi Protein Transport: A. Porat, et al.; J. Biol. Chem. 275, 14457 (2000), Application(s): WB using rat liver lysate fractions, Abstract — Full Text
- Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells: J. Hewett, et al.; Hum. Mol. Genet. 9, 1403 (2000), Application(s): ICC using mouse neural CAD cells, Abstract — Full Text
- Chromatin degradation in differentiating fiber cells of the eye lens: D. Mataic, et al.; J. Cell Biol. 137, 37 (1997), Application(s): IHC using chicken samples, Abstract
Related Products
| Application | ELISA, WB |
|---|---|
| Host | Goat |
| Species Reactivity | Mouse |
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