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MEK inhibitor
PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest.
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Product Details
| Appearance |
Pale yellow solid |
|---|---|
| CAS |
167869-21-8 |
| Couple Target |
MEK |
| Couple Type |
Inhibitor |
| Formula |
C16H13NO3 |
| MW |
267.3 |
| Purity |
≥95% (HPLC) |
| Solubility |
Soluble in DMSO (6.5mg/ml); 25mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6mg/ml). |
| Technical Info / Product Notes |
Replacement for ADI-HPK-107 |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- FJU-C28 inhibits the endotoxin-induced pro-inflammatory cytokines expression via suppressing JNK, p38 MAPK and NF-κB signaling pathways: F. Jung, et al.; Pharmacol. Res. Perspect. 9, e00876 (2021), Abstract
- Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells: K. Min, et al.; Cancers (Basel) 12, 3388 (2020), Abstract — Full Text
- Luteolin Attenuates IL-1 β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF- κ B and MAPK Pathways: W. Huang, et al.; Mediators Inflamm. 2020, 9421340 (2020), Abstract — Full Text
- PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice: J.H. Choi, et al.; Exp. Mol. Med. 50, 111 (2018), Abstract
- Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells: C.W. Lee, et al.; Redox Biol. 18, 93 (2018), Abstract — Full Text
- Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer: P. Manegold, et al.; Cancers (Basel) 10, 95 (2018), Abstract — Full Text
- Involvement of PI3K and PKA pathways in mouse tongue epithelial differentiation: J.K. Jung, et al.; Acta Histochem. 119, 92 (2017), Abstract
- Additive effects of low concentrations of estradiol-17β and progesterone on nitric oxide production by human vascular endothelial cells through shared signaling pathways: Y. Pang & P. Thomas; J. Steroid Biochem. Mol. Biol. 165, 258 (2017), Application(s): Effects on NO regulation and production, Abstract
- Interleukin-1β and Tumor Necrosis Factor-α Synergistically Induce Expression of Colony Stimulating Factors in Synovial Fibroblasts from the Human Temporomandibular Joint: S. Watanabe, et al.; Int. J. Oral-Med. Sci. 15, 74 (2017), Full Text
- Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells: N.I. Díaz-Valdivia, et al.; Oncotarget 8, 111943 (2017), Abstract — Full Text
- Calcitonin gene-related peptide is a key factor in the homing of transplanted human MSCs to sites of spinal cord injury: Y. Zhang, et al.; Sci. Rep. 6, 27724 (2016), Application(s): Migration assay in Boyden chamber, Abstract — Full Text
- AMPK activates LXRα and ABCA1 expression in human macrophages: M. Kemmerer, et al.; Int. J. Biochem. Cell Biol. 16, 30154 (2016), Application(s): Cell culture using human monocytic cells, Abstract
- Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short: Andrews, C. S., Matsuyama, S., et al.; Sci. Rep. 6, 34445 (2016), Abstract
- Avian leukosis virus subgroup J induces VEGF expression via NF-κB/PI3K-dependent IL-6 production: Gao, Y., Zhang, Y., et al.; Oncotarget 7, 80275 (2016), Application(s): Inhibition, Abstract
- Phloretin ameliorates chemokines and ICAM-1 expression via blocking of the NF-κB pathway in the TNF-α-induced HaCaT human keratinocytes: W.C. Huang, et al.; Int. Immunopharmacol. 27, 32 (2015), Application(s): Cell Culture, Western Blot, Abstract
- Nontypeable Haemophilus influenzae-Induced MyD88 Short Expression Is Regulated by Positive IKKβ and CREB Pathways and Negative ERK1/2 Pathway: Andrews, C. S., Miyata, M., et al.; PLoS One 10, e0144840 (2015), Abstract
- Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells: W. Qi, et al.; Mol. Cell. Endocrinol. 405, 74 (2015), Application(s): Cell Culture, Abstract
- All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism: R.S. Quntero Barceinas, et al.; BioMed Res. Int. 2015, Article ID 404368 (2015), Application(s): Cell Culture, Abstract — Full Text
- Mechanism of Macrophage-Derived Chemokine/CCL22 Production by HaCaT Keratinocytes: C. Yano, et al.; Ann. Dermatol. 27, 152 (2015), Application(s): Cell Culture, Abstract — Full Text
- Vinpocetine Inhibits Streptococcus pneumoniae-Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media: J.Y. Lee, et al.; J. Immunol. 194, 5990 (2015), Application(s): Cell Culture, Abstract — Full Text
- Cross Talk Between Androgen Receptor/ Filamin A And TrkA Regulates Neurite Outgrowth In PC12 Cells: M. Di Donato, et al.; Mol. Biol. Cell 26, 2858 (2015), Application(s): Cell Culture, Abstract — Full Text
- CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1/2: H. Chen, et al.; Int. J. Clin. Exp. Pathol. 8, 6700 (2015), Application(s): Cell Culture, Abstract — Full Text
- Amphiregulin may be a new biomarker of classically activated macrophages: C. Meng, et al.; Biochem. Biophys. Res. Commun. 466, 393 (2015), Application(s): Cell Culture, Abstract
- Reversible modulation of myofibroblast differentiation in adipose-derived mesenchymal stem cells: Desai, V. D., Hsia, H. C., et al.; PLoS One 9, e86865 (2014), Abstract
- From blue light to clock genes in zebrafish ZEM-2S cells: Ramos, B. C., Moraes, M. N., et al.; PLoS One 9, e106252 (2014), Application(s): In Vitro, Abstract
- Induction of interleukin-10 is dependent on p38 mitogen-activated protein kinase pathway in macrophages infected with porcine reproductive and respiratory syndrome virus: Hou, J., Wang, L., et al.; Virol. J. 9, 165 (2012), Abstract
- A mechanistic study of the effect of doxorubicin/adriamycin on the estrogen response in a breast cancer model: Pritchard, J. E., Dillon, P. M., et al.; Oncology 83, 305 (2012), Abstract
- Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells: Kaur, M., Tyagi, A., et al.; Mol. Carcinog. 50, 553 (2011), Abstract
- Mechanisms for Vascular Cell Adhesion Molecule-1 Activation of ERK1/2 during Leukocyte Transendothelial Migration: H. Abdala-Valencia, et al.; PLoS One 6, e26706 (2011), Abstract — Full Text
- Estrogen-related receptor α regulates skeletal myocyte differentiation via modulation of the ERK MAP kinase pathway: Murray, J., Huss, J. M., et al.; Am. J. Physiol. Cell Physiol. 301, C630 (2011), Abstract
- Lactobacillus rhamnosus GG attenuates interferon-{gamma} and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling: Donato, K. A., Gareau, M. G., et al.; Microbiology (Reading) 156, 3288 (2010), Abstract
- Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis: P. Xie, et al.; Am. J. Physiol. Renal Physiol. 298, F1393 (2010), Abstract — Full Text
- Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells: Tiwari, M., Bajpai, V. K., et al.; Carcinogenesis 29, 600 (2008), Abstract
- Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells: Agarwal, C., Tyagi, A., et al.; Carcinogenesis 28, 1463 (2007), Abstract
- Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells: Rubio, I., Rennert, K., et al.; Biochem. J. 398, 243 (2006), Abstract
- IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine generation is reversible and associated with increased activity of ERK1/2 and c-Fos: A. Lorentz, et al.; J. Immunol. 174, 6751 (2005), Abstract
- Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production: F.J. Dumont et al.; J Immunol 160, 2579 (1998), Abstract
- A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts: M. Tresini, et al.; Cancer Res. 58, 1 (1998), Abstract
- Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex: S.B. Waters, et al.; J. Biol. Chem. 270, 20883 (1995), Abstract
- Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation: W.J. Langlois, et al.; J. Biol. Chem. 270, 25320 (1995), Abstract
- A synthetic inhibitor of the mitogen-activated protein kinase cascade: D.T. Dudley, et al.; PNAS 92, 7686 (1995), Abstract
- Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor: L. Pang, et al.; J. Biol. Chem. 270, 13585 (1995), Abstract
- PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo: D. Alessi, et al.; J. Biol. Chem. 270, 27489 (1995), Abstract
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