PD-146176

BML-EI356

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Lipoxygenase inhibitor

A potent and selective 15-lipoxygenase inhibitor which lacks significant nonspecific antioxidant properties. It suppresses atherogenesis and limits atherosclerotic lesion development in the rabbit. It reduces oxidant stress-induced apoptosis in endothelial cells and inhibits proliferation in 15-LO overexpressing PC3 cells.

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Product Details

CAS	4079-26-9
Couple Target	Lipoxygenase
Couple Type	Inhibitor
Formula	C₁₅H₁₁NS
MW	237.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (50mg/mL) and ethanol (10mg/mL).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Solutions should be stored at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation: X. Wang, et al.; PLoS One 12, e1005803 (2016), Application(s): Pharmacological inhibition of lipoxygenase enzymes, inflammation pathway, Abstract — Full Text
Metabolites derived from omega-3 polyunsaturated fatty acids are important for cardioprotection: K. Gilbert, et al.; Eur. J. Pharmacol. 769, 147 (2015), Application(s): Cell culture, Abstract
Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells: L.M. Sordillo, et al.; Prostaglandins Other Lipid Mediat. 76, 19 (2005), Abstract
Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis: U.P. Kelavkar, et al.; Carcinogenesis 22, 1765 (2001), Abstract — Full Text
A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit: T.M. Bocan, et al.; Atherosclerosis 136, 203 (1998), Abstract
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties: S.M. Sendobry, et al.; Br. J. Pharmacol. 120, 1199 (1997), Abstract — Full Text

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PD-146176

BML-EI356

Product Details

Handling & Storage

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