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Spin trapping reagent
Cell permeable spin trap for both in vivo and in vitro studies.
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Product Details
| Alternative Name |
N-tert-Butyl-α-phenylnitrone |
|---|---|
| Appearance |
White to off-white crystalline solid. |
| CAS |
3376-24-7 |
| Formula |
C11H15NO |
| MI |
14: 7056 |
| MW |
177.3 |
| Purity |
≥98% (HPLC) |
| Solubility |
Soluble in DMSO or 100% ethanol; slightly soluble in water. |
| Technical Info / Product Notes |
For selected literature references on spin trapping and beer please click here. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Free radical formation by Lactobacillus acidophilus NCFM is enhanced by antioxidants and decreased by catalase: A.B. Hougaard, et al.; Food Res. Int. 79, 81 (2016), Application(s): Cell culture
- Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping: Myers, J. M., Cheng, Q., et al.; Free Radic. Biol. Med. 60, 183 (2013), Abstract
- In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue: K. Yamada, et al.; Free Radic. Biol. Med. 40, 2040 (2006), Abstract
- The nitrone spin trap PBN alters the cellular response to H(2)O(2): activation of the EGF receptor/ERK pathway: W.N. Hassan, et al.; Free Radic. Biol. Med. 32, 551 (2002), Abstract
- The spin trapping agent PBN stimulates H2O2 -induced Erk and Src kinase activity in human neuroblastoma cells: P. Kelicen, et al.; Neuroreport 13, 1057 (2002), Abstract
- Protective effect of spin trap agent, N-tert-butyl-alpha-phenylnitrone on hyperoxia-induced oxidative stress and its potential as a nitric oxide donor: K. Saito & H. Yoshioka; Free Radic. Res. 36, 143 (2002), Abstract
- Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059: K.R. Maples, et al.; Free Radic. Res. 34, 417 (2001), Abstract
- Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activa: P.A. Lapchak, et al.; Stroke 32, 147 (2001), Abstract — Full Text
- Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFkappaB activation offering protection against chemically induced diabetes: E. Ho, et al.; Free Radic. Biol. Med. 28, 604 (2000), Abstract
- Pharmacologic properties of phenyl N-tert-butylnitrone: Y. Kotake; Antioxid. Redox Signal. 1, 481 (1999), Review, Abstract
- Release of nitric oxide from a spin trap, N-tert-butyl-alpha-phenylnitrone, under various oxidative conditions: K. Saito, et al.; Biol. Pharm. Bull. 21, 401 (1998), Abstract
- PBN spin trapping of free radicals in the reperfusion-injured heart. Limitations for pharmacological investigations: N. Vrbjar, et al.; Mol. Cell. Biochem. 186, 107 (1998), Abstract
- The structure of free radical metabolites detected by EPR spin trapping and mass spectroscopy from halocarbons in rat liver microsomes: H. Sang, et al.; Free Radic. Biol. Med. 22, 843 (1997), Abstract
- Necrosis of the substantia nigra, pars reticulate, in flurothyl-induced status epilepticus is ameliorated by the spin trap alpha phenyl-N-tert-butyl nitrone: Q.P. He, et al.; Free Radic. Biol. Med. 22, 917 (1997), Abstract
- Evidence for a novel pentyl radical adduct of the cyclic nitrone spin trap MDL 101,002: J.L. Dage, et al.; Free Radic. Biol. Med. 22, 807 (1997), Abstract
- Optimal time and dosage of phenyl N-tert-butyl nitrone (PBN) for the inhibition of nitric oxide synthase induction in mice: T. Miyajima & Y. Kotake; Free Radic. Biol. Med. 22, 463 (1997), Abstract
- Protective action of nitrone-based free radical traps against oxidative damage to the central nervous system: R.A. Floyd; Adv. Pharmacol. 38, 361 (1997), Abstract
- N-tert-butyl-alpha-phenylnitrone: a free radical trap with unanticipated effects on diaphragm function: K.A. Andersen, et al.; J. Appl. Physiol. 80, 862 (1996), Abstract
- The spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone stimulates peroxidase-mediated oxidation of deferoxamine. Implications for pharmacological use of spin-trapping agents: M.L. McCormick, et al.; J. Biol. Chem. 270, 29265 (1995), Abstract
- Iron supplementation generates hydroxyl radical in vivo. An ESR spin- trapping investigation: M.B. Kadiiska, et al.; J. Clin. Invest. 96, 1653 (1995), Abstract
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