Patulin

ALX-270-111

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Inhibitor of protein farnesylation in a cell free assay. Inhibits incorporation of tritiated mevalonate into proteins in whole cells. Mycotoxin with anti-bacterial, potassium uptake inhibitory and possibly carcinogenic activities. Known contaminant of spoiled apples.

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Product Details

Alternative Name	4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one, Clairformin, Clavacin, Clavatin, Claviformin, Leucopin, Mycoin C3, Mycosin, Penicidin, Terinin
Appearance	White crystalline solid.
CAS	149-29-1
Couple Target	Farnesyltransferase
Couple Type	Inhibitor
Formula	C₇H₆O₄
MI	14: 7053
MW	154.1
Purity	≥98% (HPLC, TLC)
RTECS	LV2625000
Solubility	Soluble in DMSO, methanol, ethanol or water.
Source	Isolated from Penicillium expansum.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier: M. Goyer, et al.; PLoS One 11, e0149159 (2016), Application(s): Incubated into Caco-2 cells, Abstract — Full Text
Hplc detection of patulin in apple juice with GC/MS confirmation of patulin identity: J.A. Roach, et al.; Adv. Exp. Med. Biol. 504, 135 (2002), Review, Abstract
Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin: E. Pfeiffer, et al.; Carcinogenesis 19, 1313 (1998), Abstract
Inhibition of protein prenylation by patulin: S. Miura, et al.; FEBS Lett. 318, 88 (1993), Abstract
Chronology of patulin-induced alterations in membrane function of cultured renal cells, LLC-PK: R.T. Riley, et al.; Toxicol. Appl. Pharmacol. 102, 128 (1990), Abstract
Patulin: ; IARC Monographs 10, 205 (1976), Full Text
Effects of various lactones and related compounds on cation transfer in incubated cold-stored human erythrocytes: J.B. Kahn, Jr.; J. Pharmacol. Exp. Ther. 121, 234 (1957), Abstract
Patulin in the common cold – Collaborative research on a derivative of Penicillium patulum bainier – II. Biochemistry and Chemistry: M. Birkinshaw, et al.; Lancet 245, 625 (1943), Abstract

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Patulin

ALX-270-111

Product Details

Handling & Storage

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