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PATHO-GENE^® HPV type 16/18/31/33/51 probe

ENZ-32882

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HPV probe that can be optimized for use with polymer detection system or used as optimized RTU with Enzo’s Streptavidin detection methods.

The PATHO-GENE^® HPV type 16/18/31/33/51 probe is a mixture of biotin-labeled HPV-16, HPV- 18, HPV-31, HPV-33 and HPV-51 specific probes in buffered formamide and hybridization enhancers.

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PATHO-GENE HPV 16-18-31-33-51 Negative Detection Vulva — Negative detection of HPV 16/18/31/33/51 with ENZ-32882 PATHO-GENE® HPV 16/18/31/33/51 probes in vulva FFPE tissue.

PATHO-GENE HPV 16-18-31-33-51 Positive Detection Cervix — Positive detection of HPV 16/18/31/33/51 with ENZ-32882 PATHO-GENE® HPV 16/18/31/33/51 probes in HPV infected cervical FFPE tissue.

Product Details

Application Notes	The PATHO-GENE^® HPV type 16/18/31/33/51 probe employs a mixture of the HPV-16, HPV -18, HPV-31, HPV-33 and HPV-51 specific probes that detect HPV types that have been associated with either condyloma or cervical intraepithelial neoplasia (CIN) and carcinoma in situ (CIS). The probe mixture is denatured and hybridized to the tissue section fixed and pretreated on the microscope slide. Specific hybridization between the HPV DNA probe and DNA in the specimen is determined by the detection of biotin.
Technical Info / Product Notes	HPV probe can be optimized for polymer detection system using diluent buffer, In situ hybridization buffer for HPV probes (Ready-to-Use) (Prod. No. ENZ-33905). This product or the use of this product is covered by one or more Enzo patents, including, but not limited to the following: U.S. Patent No. 4,994,373; Canadian Patent No. 1,309,672; and patents pending.

Application Notes

The PATHO-GENE^® HPV type 16/18/31/33/51 probe employs a mixture of the HPV-16, HPV -18, HPV-31, HPV-33 and HPV-51 specific probes that detect HPV types that have been associated with either condyloma or cervical intraepithelial neoplasia (CIN) and carcinoma in situ (CIS). The probe mixture is denatured and hybridized to the tissue section fixed and pretreated on the microscope slide. Specific hybridization between the HPV DNA probe and DNA in the specimen is determined by the detection of biotin.

Technical Info / Product Notes

HPV probe can be optimized for polymer detection system using diluent buffer, In situ hybridization buffer for HPV probes (Ready-to-Use) (Prod. No. ENZ-33905).

This product or the use of this product is covered by one or more Enzo patents, including, but not limited to the following: U.S. Patent No. 4,994,373; Canadian Patent No. 1,309,672; and patents pending.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least one year after receipt when stored as recommended. Following dilution in appropriate buffer system, product is stable for at least 2 days.
Handling	Allow contents to warm up to room temperature prior to use.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Penile squamous cell carcinoma exclusive to the shaft, with a proposal for a novel staging system: B. Tekin, et al.; Human Pathol. 134, 92 (2023), Abstract
CEA as a blood-based biomarker in anal cancer: R. Hester, et al.; Oncotarget 12, 1037 (2021), Abstract — Full Text
RNA in-situ hybridization is a practical and effective method for determining HPV status of oropharyngeal squamous cell carcinoma including discordant cases that are p16 positive by immunohistochemistry but HPV negative by DNA in-situ hybridization: L.M. Rooper, et al.; Oral Oncol. 55, 11 (2016), Application(s): Evaluation for HPV DNA was performed, Abstract
The utility of p16 immunostaining in fine needle aspiration in p16-positive head and neck squamous cell carcinoma: B. Xu, et al.; Hum. Pathol. 54, 193 (2016), Abstract
A proportion of primary squamous cell carcinomas of the parotid gland harbor high risk human papillomavirus: B. Xu, et al.; Histopathology 69, 921 (2016), Abstract

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PATHO-GENE^® HPV type 16/18/31/33/51 probe

ENZ-32882

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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PATHO-GENE® HPV type 16/18/31/33/51 probe

ENZ-32882

Product Details

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