Home Shop PARP-2 monoclonal antibody (4G8)

PARP-2 monoclonal antibody (4G8)

ALX-804-639

10 citations

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This antibody is covered by our Worry-Free Guarantee.

TRIP-Br1 monoclonal antibody (TB1-27/2) Western blot

Product Details

Alternative Name	Poly(ADP-ribose) polymerase-2
Application	ELISA, WB
Application Notes	Detects a band of ~62kDa by Western blot.
Clone	4G8
Formulation	Liquid. Tissue culture supernatant containing 0.1% sodium azide.
Host	Mouse
Immunogen	Recombinant mouse PARP-2 (poly(ADP-ribose) polymerase-2).
Isotype	IgG1
Recommendation Dilutions/Conditions	ELISA (1:500)Western Blot (1:20-1:50)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse
Specificity	Recognizes an epitope in domain E of PARP-2.
UniProt ID	O88554
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites: Lin, X., Leung, K. S. K., et al.; Nucleic Acids Res. 53, gkaf086 (2025), Abstract
PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress.: Muoio, D., Laspata, N., et al.; Nat. Commun. 15, 2857 (2024), Application(s): WB, Abstract
Redundant but essential functions of PARP1 and PARP2 in DNA ligase I-independent DNA replication: Bhandari, S. K., Wiest, N., et al.; Nucleic Acids Res. 52, 10341 (2024), Abstract
Quantitative Analysis of Nuclear Poly(ADP-Ribose) Dynamics in Response to Laser-Induced DNA Damage.: Koczor, C. A., Saville, K. M., et al.; Methods Mol. Biol. 2609, 43 (2022), Reactant(s): Human, Abstract
Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis.: Sobol, R. W., McClellan, S., et al.; Cell Rep. 37, 109917 (2021), Reactant(s): Human, Abstract
Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.: Ahel, I., Halic, M., et al.; Nature 585, 609 (2020), Application(s): WB, Abstract
HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation: Suskiewicz, M. J., Zobel, F., et al.; Nature 579, 598 (2020), Abstract
PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection.: Amor-Guéret, M., Hall, J., et al.; Nucleic Acids Res. 45, 12325 (2017), Application(s): IF / Reactant(s): Human, Abstract
CCCTC-binding Factor Activates PARP-1 Affecting DNA Methylation Machinery: T. Guastafierro, et al.; J. Biol. Chem. 283, 21873 (2008), Abstract — Full Text
Anti-Poly-ADP-Ribose Polymerase-2 (PARP-2) Mouse MAb 4G8: Y. Monreal, et al.; Hybridoma 25, 102 (2006), Abstract

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PARP-2 monoclonal antibody (4G8)

ALX-804-639

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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