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PAPA NONOate

ALX-430-016

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Nitric oxide donor

Nitric oxide (NO) donor. The half-life time of PAPA NONOate is 76.6 min. at 22°C in 0.1M phosphate buffer, pH 7.4. Decomposition of NONOates is nearly instantaneous at pH 5.0.

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Product Details

Alternative Name	PAPA/NO, NOC-15, (Z)-1-[N-(3-Ammoniopropyl)-N-(n-propyl)amino]diazen-1-ium-1,2-diolate
Appearance	White to off-white solid.
CAS	146672-58-4
Formula	C₆H₁₆N₄O₂
MW	176.2
Purity	≥97% (TLC)
Solubility	Soluble in water or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Relatively stable in alkaline solution.
Handling	Protect from moisture. Keep under inert gas.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Characterisation and comparison of temporal release profiles of nitric oxide generating donors: S.A. Bradley & J.R. Steinert; J. Neurosci. Methods 245, 116 (2015), Application(s): Nitric Oxide Donor, Abstract
Dual effects of nitric oxide on the large conductance calcium-activated potassium channels of rat brain: J.E. Lee, et al.; J. Biochem. Mol. Biol. 39, 91 (2006), Abstract
Role of nitric oxide-induced mtDNA damage in mitochondrial dysfunction and apoptosis: L.I. Rachek, et al.; Free Radic. Biol. Med. 40, 754 (2006), Abstract
Nitric oxide inhibits cAMP-dependent CFTR trafficking in intestinal epithelial cells: A.C. Skinn & W.K. MacNaughton; Am. J. Physiol. Gastrointest. Liver Physiol. 289, G739 (2005), Abstract — Full Text
Nitric oxide donors alter cardiomyocyte cytokine secretion and cardiac function: D.L. Maass, et al.; Crit. Care Med. 33, 2794 (2005), Abstract
Position in cell cycle controls the sensitivity of colon cancer cells to nitric oxide-dependent programmed cell death: A. Jarry, et al.; Cancer Res. 64, 4227 (2004), Abstract
Effects of redox-related congeners of NO on apoptosis and caspase-3 activity: J. Haendeler, et al.; Nitric Oxide 1, 282 (1997), Abstract
New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)

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PAPA NONOate

ALX-430-016

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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