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Panepoxydone

ALX-350-109

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NF-κB pathway inhibitor

Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.

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Product Details

Appearance	Yellow oil.
CAS	31298-54-1
Couple Target	IkappaB, NF-kappaB
Couple Type	Inhibitor
Formula	C₁₁H₁₄O₄
MW	210.2
Purity	≥95% (HPLC, MS)
Solubility	Soluble in DMSO, 100% ethanol or methanol.
Source	Isolated from Lentinus crinitus.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Keep cool and dry. After reconstitution, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus: R.E. Watkinson, et al.; PLoS Pathog. 11, e1005253 (2015), Application(s): NF-κB inhibitor, Abstract — Full Text
Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers: Arora, R., Schmitt, D., et al.; Oncotarget 6, 662 (2015), Abstract
Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer: Arora, R., Yates, C., et al.; PLoS One 9, e98370 (2014), Abstract
Tumor necrosis factor (TNF)-alpha upregulates progesterone receptor-A by activating the NF-kappaB signaling pathway in human decidua after labor onset: Z.Y. Jiang, et al.; Placenta 33, 1 (2012), Abstract
Activation of cytokine expression occurs through the TNFalpha/NF-kappaB-mediated pathway in birnavirus-infected cells: W.L. Wang, et al.; Fish Shellfish Immunol. 31, 10 (2011), Abstract
Regulation of glycosyltransferases and Lewis antigens expression by IL-1beta and IL-6 in human gastric cancer cells: M. Padro, et al.; Glycoconj. J. 28, 99 (2011), Abstract
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells: G. Erkel, et al.; Int. Immunopharmacol. 7, 612 (2007), Abstract
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter: M. Ramanathan, et al.; Mol. Biol. Cell 18, 14 (2007), Abstract — Full Text
Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent: J.B. Shotwell, et al.; Bioorg. Med. Chem. Lett. 12, 3463 (2002), Abstract
Molecular design and biological activities of NF-kappaB inhibitors: K. Umezawa & C. Chaicharoenpong; Mol. Cells 14, 163 (2002), Abstract

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Panepoxydone

ALX-350-109

Product Details

Handling & Storage

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