PACOCF3

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Phospholipase inhibitor

Inhibitor of both Ca²⁺-dependent cytosolic cPLA₂ (IC₅₀=45 µM) and Ca²⁺-independent phospholipases A₂iPLA₂ (IC₅₀=3.8 µM).

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Alternative Name	Palmityl trifluoromethylketone, PTK
Appearance	White to off-white solid.
CAS	141022-99-3
Couple Target	Phospholipase
Couple Type	Inhibitor
Formula	C₁₇H₃₁F₃O
MW	308.4
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol, dimethyl formamide or DMSO (warm); sparingly soluble in neutral buffers.
Technical Info / Product Notes	Note: Product is not sterile.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. Not stable in basic solutions (pH > 7.4). We do not recommend storing aqueous solutions for more than one day.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Activated ketones as inhibitors of intracellular Ca2+-dependent and Ca2+-independent phospholipase A: K. Conde-Friesboes, et al.; JACS 118, 5519 (1996)
Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones: E.J. Ackermann, et al.; J. Biol. Chem. 270, 445 (1995), Abstract — Full Text

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