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Natural diterpenoid isolated from the stem bark of the Pacific yew tree (Taxus brevifolia Nutt.). It promotes the assembly of stable microtubules and inhibits the disassembly process of microtubules to tubulin by calcium ions and by low temperature. Taxol was shown to have activity against cancers, such as P388 and L1210 leukemia, B16 melanoma, WM-256 carcinosarcoma, Sarcoma 180, Lewis lung tumor, and several xenografts of human tumors including MX-1 mammary, LX-11.
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