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Paclitaxel

BML-T104

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Ultra-pure; stabilizes microtubules

Antitumor agent. Stabilizes microtubules and lowers the critical concentration for tubulin polymerization. Reversibly binds to polymerized tubulin. Inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells. The checkpoint of mitotic spindle assembly, aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK) are involved in Paclitaxel-induced apoptosis.

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Product Details

Appearance	White solid.
CAS	33069-62-4
Formula	C₄₇H₅₁NO₁₄
MI	14: 6982
MW	853.9
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO or methanol at 10mg/ml.
Source	Isolated from the bark of the Pacific Yew tree (Taxus brevifolia).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 6 months.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Tubulin-Based Microtentacles Aid in Heterotypic Clustering of Neutrophil-Differentiated HL-60 Cells and Breast Tumor Cells: Ju, J. A., Thompson, K. N., et al.; Adv. Sci. (Weinh.) 12, e2409260 (2025), Abstract
StableMARK-decorated microtubules in cells have expanded lattice: L. de Jager, et al.; J. Cell Biol. 224, e202206143 (2024), Abstract
Lattice Light-Sheet Motor-PAINT: A Method to Map the Orientations of Microtubules in Complex Three-Dimensional Arrays: Iwanski, M. K., Katrukha, E. A., et al.; Methods Mol. Biol. 2694, 151 (2023), Abstract
FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer: S. Tavares, et al.; Cell Rep. 39, 110584 (2022), Abstract
Relative refractoriness of breast cancer cells to tumour necrosis factor-α induced necroptosis: B. Thakur, et al.; Clin. Exp. Pharmacol. Physiol. 49, 1294 (2022), Abstract
Portoamides A and B are mitochondrial toxins and induce cytotoxicity on the proliferative cell layer of in vitro microtumours: M. Ligia Sousa, et al.; Toxicon 175, 49 (2020), Abstract
Know your ABCs: Characterization and gene expression dynamics of ABC transporters in the polyphagous herbivore Helicoverpa armigera: A. Bretschneider, et al.; Insect. Biochem. Mol. Biol. 72, 1 (2016), Application(s): Cell culture, Abstract
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al.; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract — Full Text
End-binding proteins sensitize microtubules to the action of microtubule-targeting agents: Mohan, R., Katrukha, E. A., et al.; PNAS 110, 8900 (2013), Abstract

Last modified: May 29, 2024

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Paclitaxel

BML-T104

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