p70 S6 kinase (human), (recombinant)

p70 S6K was first identified as the kinase responsible for the phosphorylation of the S6 ribosomal protein. Research has raised the possibility that S6K might, in fact, be the rapamycin-sensitive effector responsible for directly phosphorylating IRS-1 and thereby inhibiting PI 3-kinase activation. Another study suggests that S6K1 activation may mediate some of the effects of a high-fat diet on inhibiting the insulin-PI 3-kinase signaling pathway3. This makes S6K1 a promising new therapeutic target in the fight against type 2 diabetes.