p62 (human), (recombinant) (GST-tag)

The p62 protein functions as a ubiquitin (Ub)-binding scaffold, which regulates a diverse range of signalling pathways leading to activation of the nuclear factor kappa B (NF-κB) family of transcription factors. p62 also plays an important role in the control of induced osteoclastogenesis,and mutations affecting the SQSTM1 gene are commonly found in patients with the skeletal disorder Paget’s disease of bone (PDB). The vast majority of the PDB associated mutations identified cluster within the UBA domain, impairing p62’s ability to bind Ub and resulting in dysregulated NF-κB signalling.

p62 is a critical regulator of the degradation of ubiquitinated proteins by macroautophagy.The p62 protein has a domain structure consistent with its participation in multiple signalling complexes, including a C-terminal Ub-associated (UBA) domain through which p62 binds non-covalently to Ub and a LC3 interacting region (LIR), facilitating simultaneous binding to ubiquitinylated proteins and the autophagic machinery via LC3/GABARAP. As a result p62 acts as an important substrate receptor for selective autophagy.