P62, also known as Sequestosome I, is a 62kDa, 440 amino acid protein, initially identified as a ligand of the SH2 domain of p56lck, now known to be expressed in many tissues. In addition to TRAF6, PEST and zinc finger motifs, p62 has a C-terminal ubiquitin binding association (UBA) domain with an affinity for multi-ubiquitin chains, and it is considered to serve as a scaffold protein, capable of binding to multiple signalling molecules and uniting receptor-mediated signalling events with ubiquitinylation. Elevated levels of p62 have been reported in breast tumours and in alcoholic liver disease where p62 has been shown to be involved in the formation of Mallory bodies. Several mutations in the p62 UBA domain have been identified and the etiology of Paget’s disease of bone has been linked to one such mutation. Kuusisto and colleagues have demonstrated that p62 is also present in elevated levels in the hallmark inclusions found in various neurodegenerative conditions, including tauopathies (Alzheimer’s disease, Picks disease, and frontotemporal dementia) and synucleinopathies (Parkinson’s disease, dementia with Lewy body disease and multiple system atrophy). In recent years ubiquitin immunostaining has been used to provide adjunct information for neuropathological diagnosis, but it is becoming evident that p62 may be an even more reliable marker of neurodegenerative disease inclusion detection than tau, alpha-synuclein or ubiquitin immunostaining.
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Immunohistochemistry analysis of p62 immunoreactivity is present in neurons of the hippocampus of an Alzheimer patient. Note the intense reaction in the neurofibrillary tangles (dilution 1:1000).
Micrograph courtesy of Professor Fred van Leeuwen, University of Maastricht, The Netherlands.

Western blot analysis of wild type p62, GST-tagged (human, recombinant) bound to: (1) glutathione-agarose and (3) ubiquitin-agarose (2: agarose control). Bound species were analysed by PAGE followed by blotting on to PVDF and probing with Prod. No. BML-PW9860.

Suppression of LRPPRC leads to enhancement of basal levels of autophagy in native HeLa cells(A) Immunoblot analyses of LC3 isoforms in lysates from HeLa cells treated with random siRNA (Mock) or LRPPRC-specific siRNA (LRPPRC) in the absence (Ctrl) or presence of lysosomal inhibitor NH4Cl. Molecular masses are indicated in kDa. (B) Plots of relative intensities of LC3-I and LC3-II bands. The LC3-I and LC3-II intensities in samples treated with mock siRNA were set to 1. Results are means±S.D. of at least three repeats and the differences were compared using a paired Student’s t test. *P≤0.05. (C) Transmission electron microscopy imaging of HeLa cells treated with random siRNA (Mock) or LRPPRC-specific siRNA (LRPPRC) in the absence (Ctrl) or presence (BAF) of lysosomal inhibitor bafilomycin A1. *, autophagy vacuoles. (D) Plot of percentages of area occupied by autophagy vacuoles in the transmission electron microscopy images. Results are means±S.D. of at least three repeats and the differences were compared using Student’s t test. *P≤0.05. (E) Immunoblot (IB) analyses of p62 levels in lysates from HeLa cells treated with random siRNA (Mock) or LRPPRC-specific siRNA (LRPPRC) in the absence (Ctrl) or presence (BAF) of bafilomycin A1. (F) Plots of relative intensities of p62. The p62 intensities in samples treated with mock siRNA were set to 1. Results are means±S.D. of at least three repeats and the differences were compared using a paired Student’s t test. *P≤0.05. (G) Immunostaining analysis of p62 levels in HeLa cells treated with random siRNA (Mock) or LRPPRC-specific siRNA (LRPPRC) in the absence (Ctrl) or presence (BAF) of bafilomycin A1.
Image collected and cropped by CiteAb under a CC-BY license from the following publication: Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability. Biochem J (2013)

The changes of expressions of LC3, Beclin 1, p62 and Bcl-2 after 3-MA treatment.(A–C) The changes of LC3, Beclin 1 and p62 after the treatment of 3-MA. 3-MA downregulated the ratio of LC3-II/LC3-I and the expression of Beclin 1, and upregulated the expression of p62 as compared with that in I/R-24 h or I/R+Veh group. (D) The expression of Bcl-2 after the treatment of 3-MA. The expression of Bcl-2 decreased at 24 h postischemia, however, IPOC or treatment with 3-MA partially resulted in the recovery of Bcl-2. Levels of β-actin protein were used as the loading control. n = 5 for each group. *p<0.05 vs. the Sham group; #p<0.05 vs. I/R-24 h group; $p<0.05 vs. I/R+Veh group.
Image collected and cropped by CiteAb under a CC-BY license from the following publication: Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats. PLoS One (2012)




Product Details
Alternative Name |
SQSTM1, Sequestosome I |
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Application |
ELISA, IF, IHC, WB |
Formulation |
Liquid. In PBS containing 0.09% sodium azide. |
Host |
Rabbit |
Immunogen |
Synthetic peptide corresponding to aa 387-436 human p62. |
Purity Detail |
Peptide affinity purified. |
Recommendation Dilutions/Conditions |
Immunohistochemistry (1:1,000)Western Blot (1:1,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
Source |
Purified from rabbit serum. |
Species Reactivity |
Human |
Technical Info / Product Notes |
Cited samples: |
UniProt ID |
Q13501 |
Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
Handling |
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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Long Term Storage |
-20°C |
Shipping |
Blue Ice |
Regulatory Status |
RUO – Research Use Only |
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- TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy: Levi-D’Ancona, E., Walker, E. M., et al.; bioRxiv , (2025)
- Atg5 in microglia regulates sex-specific effects on postnatal neurogenesis in Alzheimer’s disease: Walter, E., Angst, G., et al.; NPJ Aging 11, 18 (2025), Abstract
- Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders: Newton, F., Halachev, M., et al.; Nat. Commun. 16, 4024 (2025), Abstract
- Reduced Palmitoylation of SQSTM1/p62 in Huntington Disease Is Associated With Impaired Autophagy: Abrar, F., Davies, M. C., et al.; FASEB J. 39, e70549 (2025), Abstract
- Two FAM134B isoforms differentially regulate ER dynamics during myogenesis: Buonomo, V., Lohachova, K., et al.; EMBO J. 44, 1039 (2025), Abstract
- Comprehensive knockout analysis of the RAB family small GTPases reveals an overlapping role of RAB2 and RAB14 in autophagosome maturation: Haga, K., Fukuda, M., et al.; Autophagy 21, 21 (2025), Abstract
- Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders: Newton, F., Halachev, M., et al.; bioRxiv , (2024)
- Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling: Simpson, J. E., Muir, M. T., et al.; Dev. Cell 59, 228 (2024), Abstract
- O-GlcNAc transferase acts as a critical nutritional node for the control of liver homeostasis: Ortega-Prieto, P., Parlati, L., et al.; JHEP Rep. 6, 100878 (2024), Application(s): WB, Abstract
- SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis: Xia, Q., Zheng, H., et al.; Autophagy 20, 735 (2024), Abstract
- The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation: Makar, A. N., Boraman, A., et al.; Nat. Commun. 15, 7743 (2024), Abstract
- A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements: Martin, S., Scorzoni, S., et al.; Science 385, eadj7446 (2024), Abstract
- AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer: Yeo, S. K., Haas, M., et al.; Autophagy 20, 525 (2024), Abstract
- Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense: Choi, E. J., Oh, H. T., et al.; Autophagy 20, 2490 (2024), Abstract
- Skin biopsies for diagnosing neuronal intranuclear inclusion disease: A retrospective study of 12 cases: S. Itamoto, et al,; J. Dermatol. , (2023), Reactant(s) Human, Abstract
- Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy.: Xia, Q., Li, Y., et al.; Cell Biosci. 13, 37 (2023), Application(s): ICC-IF, WB, Abstract
- The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes.: Wu, S. A., Shen, C., et al.; Nat. Commun. 14, 3132 (2023), Application(s): WB / Reactant(s): Mouse, Abstract
- Chlorpromazine affects autophagy in association with altered Rag GTPase-mTORC1-TFEB signaling.: Li, N., Rao, L., et al.; Front Cell Dev Biol 11, 1266198 (2023), Application(s): WB / Reactant(s): Human, Abstract
- Autophagy maintains the homeostatic environment in the male reproductive accessory organs playing a key role in fertility: Jaulim, A., Cassidy, L. D., et al.; bioRxiv , (2023), Application(s): IHC / Reactant(s): Mouse
- An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy: Gingerich, M. A., Liu, X., et al.; Autophagy 19, 525 (2023), Abstract
- Nanosensor-based monitoring of autophagy-associated lysosomal acidification in vivo: Kim, M., Chen, C., et al.; Nat. Chem. Biol. 19, 1448 (2023), Abstract
- Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland: Zhang, X., Young, C., et al.; JCI Insight 8, (2023), Abstract
- Reduced S-acylation of SQSTM1/p62 in Huntington disease is associated with impaired autophagy: Abrar, F., Davies, M., et al.; bioRxiv , (2023)
- Glycan degradation promotes macroautophagy: A.D. Baudot, et al.; PNAS 119, e2111506119 (2022), Application(s): WB, Abstract
- Protective function of the SQSTM1/p62-NEDD4 complex against methylmercury toxicity: Y. Takanezawa, et al.; Biochem. Biophys. Res. Commun. 609, 134 (2022), Abstract
- ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis: J.S. Long, et al.; PNAS 119, e2113465119 (2022), Application(s): WB / Reactant(s) Mouse, Abstract
- MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma: P.F. Liu, et al.; J. Cell. Physiol. 237, 4275 (2022), Application(s): IHC, Abstract
- Transient Systemic Autophagy Inhibition is Selectively and Irreversibly Deleterious to Lung Cancer: K. Khayati, et al.; Cancer Res. 82, 4429 (2022), Abstract
- Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.: Ktistakis, N., Pluschke, G., et al.; Autophagy 18, 841 (2022), Application(s): ICC-IF, Abstract
- Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner.: Han, D., Li, S., et al.; FEBS Open Bio 12, 118 (2022), Application(s): WB / Reactant(s): Human, Abstract
- Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1.: Magistrati, E., Maestrini, G., et al.; EMBO Rep. 23, e54160 (2022), Application(s): WB, Abstract
- Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice.: Mainz, L., Sarhan, M. A. F. E., et al.; Autophagy 18, 2880 (2022), Application(s): IHC, Abstract
- Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53.: Mainz, L., Sarhan, M. A. F. E., et al.; Front Cell Dev Biol 10, 785252 (2022), Application(s): IHC / Reactant(s): Mouse, Abstract
- Methamphetamine Dysregulates Macrophage Functions and Autophagy to Mediate HIV Neuropathogenesis.: Barbaro, J. M., Sidoli, S., et al.; Biomedicines 10, (2022), Application(s): WB, Abstract
- Combined Evaluation of MAP1LC3B and SQSTM1 for Biological and Clinical Significance in Ductal Carcinoma of Breast Cancer: P.F. Liu, et al.; Biomedicines 9, 1514 (2021), Abstract
- Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course: R. Maroofian, et al.; Brain Commun. 3, 1093 (2021), Abstract
- Gαq activation modulates autophagy by promoting mTORC1 signaling: S. Cabezudo, et al.; Nat. Commun. 12, 4540 (2021), Application(s): WB / Reactant(s) Human, Mouse, Rat, Abstract
- Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis: A. Di Spiezio, et al.; Biochim. Biophys. Acta Mol. Basis Dis. 1867, 166205 (2021), Abstract
- Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser352: J.Y. Park, et al.; Sci. Rep. 11, 8430 (2021), Abstract
- Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination: C. Blázquez, et al.; Elife 9, 5681 (2021), Application(s): ICC-IF, WB / Reactant(s) Mouse, Abstract — Full Text
- TBK1 haploinsufficiency results in changes in the K63-ubiquitination profiles in brain and fibroblasts from affected and presymptomatic mutation carriers: B. Khoshnood, et al.; J. Neurol. , (2021), Abstract
- DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries: L. Bouche, et al.; PLoS One 16, 248554 (2021), Abstract
- Loss of autophagy affects melanoma development in a manner dependent on PTEN status: M.T. Rosenfeldt, et al.; Cell Death Differ. 28, 1437 (2021), Application(s): IHC / Reactant(s) Mouse, Abstract
- The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity: R. Jia & J.S. Bonifacino; J. Biol. Chem. 296, 100405 (2021), Application(s): IF / Reactant(s) Human, Abstract
- 1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.: Thiele, C., Latz, E., et al.; Autophagy 17, 1947 (2021), Application(s): ICC-IF, WB / Reactant(s): Mouse, Abstract
- Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction.: Stroobants, S., D’Hooge, R., et al.; Brain Pathol. 31, 223 (2021), Reactant(s): Mouse, Abstract
- Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination.: O’Malley, B. W., He, B., et al.; Elife 10, (2021), Application(s): WB, Abstract
- HIV Increases the Inhibitory Impact of Morphine and Antiretrovirals on Autophagy in Primary Human Macrophages: Contributions to Neuropathogenesis.: Cuervo, A. M., Berman, J. W., et al.; Cells 10, (2021), Application(s): ICC-IF, WB, Abstract
- ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress.: Lizcano, J. M., Yoldi, G., et al.; Front Cell Dev Biol 9, 742049 (2021), Application(s): WB, Abstract
- TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex.: Kroemer, G., Micheau, O., et al.; Cells 11, (2021), Reactant(s): Human, Abstract
- Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice: Caballero, B., Bourdenx, M., et al.; Nat. Commun. 12, 2238 (2021), Abstract
- Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles: Hao, M., Yeo, S. K., et al.; Dev. Cell 56, 341 (2021), Abstract
- Bromamine T (BAT) Exerts Stronger Anti-Cancer Properties than Taurine (Tau): Baliou, S., Goulielmaki, M., et al.; Cancers (Basel) 13, (2021), Abstract
- Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome: Bourdenx, M., Martín-Segura, A., et al.; Cell 184, 2696 (2021), Abstract
- IRGM1 links mitochondrial quality control to autoimmunity: Rai, P., Janardhan, K. S., et al.; Nat. Immunol. 22, 312 (2021), Abstract
- Isolation of an Extract from the Soft Coral Symbiotic Microorganism Salinispora arenicola Exerting Cytoprotective and Anti-Aging Effects: Louka, X. P., Sklirou, A. D., et al.; Curr. Issues Mol. Biol. 44, 14 (2021), Abstract
- Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease: Bassal, M., Liu, J., et al.; Cells 10, (2021), Abstract
- Characterization of two types of intranuclear hepatocellular inclusions in NAFLD: S. Schwertheim, et al.; Sci. Rep. 10, 16533 (2020), Application(s): IHC-IF / Reactant(s) Human, Abstract — Full Text
- Sel1L-Hrd1 ER-associated degradation maintains β-cell identity via TGFβ signaling: N. Shrestha, et al.; J. Clin. Invest. 130, 3499 (2020), Abstract — Full Text
- Downregulation of miR-335-5P in Amyotrophic Lateral Sclerosis Can Contribute to Neuronal Mitochondrial Dysfunction and Apoptosis: N. De Luna, et al.; Sci. Rep. 10, 4308 (2020), Application(s): IHC, WB / Reactant(s) Human, Abstract — Full Text
- Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes.: Bowman, A. B., Singh, R., et al.; Autophagy 16, 1506 (2020), Application(s): ICC-IF, WB / Reactant(s): Mouse, Abstract
- HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies.: Brunton, V. G., Muir, M., et al.; Breast Cancer Res. Treat. 179, 543 (2020), Application(s): IHC, Abstract
- Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington’s disease.: Green, K. N., Thompson, L. M., et al.; Brain 143, 266 (2020), Application(s): IHC / Reactant(s): Mouse, Abstract
- Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.: Passos, J. F., Ktistakis, N. T., et al.; Nat. Commun. 11, 307 (2020), Application(s): IHC, Abstract
- HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders.: Cuervo, A. M., Berman, J. W., et al.; Cells 9, (2020), Application(s): WB / Reactant(s): Human, Abstract
- mTORC1 and JUN are activated after deletion of Prohibitin 1 in Schwann cells and may link mitochondrial dysfunction to demyelination: He, B., Wrabetz, L., et al.; bioRxiv , (2020), Application(s): WB
- Discovery of a protein uptake pathway in lysosomes: Fujiwara, Y., Contu, V. R., et al.; bioRxiv , (2020)
- Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis: Marques, A. R. A., Di Spiezio, A., et al.; Autophagy 16, 811 (2020), Abstract
- FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function: Okamoto, T., Yeo, S. K., et al.; Cancer Res. 80, 3580 (2020), Abstract
- TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62: J.Y. Park, et al.; Sci. Rep. 9, 14354 (2019), Abstract — Full Text
- SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy: M. Ullrich, et al.; J. Mol. Cell. Cardiol. 129, 12 (2019), Abstract
- Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice: G.E. Farias Quipildor, et al.; Geroscience 41, 185 (2019), Application(s): WB, Abstract — Full Text
- Autophagy Regulates Craniofacial Bone Acquisition: N. Thomas, et al.; Calcif. Tissue Int. 105, 518 (2019), Application(s): WB, Abstract — Full Text
- A genetic model of CEDNIK syndrome in zebrafish highlights the role of the SNARE protein Snap29 in neuromotor and epidermal development: V. Mastrodonato, et al.; Sci. Rep. 9, 1211 (2019), Application(s): Zebrafish, Abstract — Full Text
- Autophagy flux in critical illness, a translational approach: N. Tardif, et al.; Sci. Rep. 9, 10762 (2019), Application(s): ICC-IF, IF / Reactant(s) Human, Abstract — Full Text
- A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival: L. von Kleist, et al.; Mol. Genet. Metab. 126, 196 (2019), Abstract
- Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.: Ling, S. C., Dastidar, S. G., et al.; Elife 8, (2019), Reactant(s): Mouse, Abstract
- Molecular insights into an ancient form of Paget’s disease of bone.: Kessler, B. M., Layfield, R., et al.; PNAS 116, 10463 (2019), Application(s): WB / Reactant(s): Human, Abstract
- Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3.: Jia, R., Bonifacino, J. S., et al.; Elife 8, (2019), Application(s): IF / Reactant(s): Human, Abstract
- Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.: Guan, J. L., Chen, S., et al.; Nat. Metab. 1, 1127 (2019), Application(s): IHC, Abstract
- Temporal inhibition of autophagy reveals segmental reversal of aging with increased cancer risk: Narita, M., Jurk, D., et al.; bioRxiv , (2019), Application(s): IHC / Reactant(s): Mouse
- BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes: Ji, C., Tang, M., et al.; Autophagy 15, 1199 (2019), Abstract
- Cellular response to glutamine and/or glucose deprivation in in vitro transformed human fibroblasts: Chiodi, I., Picco, G., et al.; Oncol. Rep. 41, 3555 (2019), Abstract
- Mice deficient in the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) display a complex retinal phenotype: Atiskova, Y., Bartsch, S., et al.; Sci. Rep. 9, 14185 (2019), Abstract
- Negative Regulation of Autophagy by UBA6-BIRC6–Mediated Ubiquitination of LC3: Jia, R., Bonifacino, J. S., et al.; bioRxiv , (2019)
- Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model: Zhou, Y., Carmona, S., et al.; J. Clin. Invest. 129, 1756 (2019), Abstract
- Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7: S. Sukseree, et al.; Mol. Neurobiol. 55, 8425 (2018), Application(s): WB, Abstract — Full Text
- Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation: T. Danyukova, et al.; Hum. Mol. Genet. 27, 1711 (2018), Application(s): WB / Reactant(s) Mouse, Abstract — Full Text
- Elevated Peripheral Myelin Protein 22, Reduced Mitotic Potential, and Proteasome Impairment in Dermal Fibroblasts from Charcot-Marie-Tooth Disease Type 1A Patients: S. Lee, et al.; Am. J. Pathol. 188, 728 (2018), Abstract
- NoxO1 Controls Proliferation of Colon Epithelial Cells: F. Moll, et al.; Front. Immunol. 9, 7973 (2018), Application(s): WB, Abstract — Full Text
- Ischemic Postconditioning Alleviates Cerebral Ischemia-Reperfusion Injury Through Activating Autophagy During Early Reperfusion in Rats: Y. Sun, et al.; Neurochem. Res. 43, 1826 (2018), Application(s): IHC / Reactant(s) Rat, Abstract — Full Text
- Homozygous TBC1 domain-containing kinase (TBCK) mutation causes a novel lysosomal storage disease – a new type of neuronal ceroid lipofuscinosis (CLN15)?: S. Beck-Wodl, et al.; Acta Neuropathol. Commun. 6, 145 (2018), Application(s): IHC / Reactant(s) Human, Abstract — Full Text
- TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.: Nüchel, J., Ghatak, S., et al.; Autophagy 14, 465 (2018), Application(s): WB / Reactant(s): Human, Abstract
- Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.: Hayden, M. R., Ehrnhoefer, D. E., et al.; Acta Neuropathol. Commun. 6, 16 (2018), Application(s): WB, Abstract
- A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.: Cassidy, L. D., Young, A. R., et al.; Autophagy 14, 1256 (2018), Application(s): IHC / Reactant(s): Mouse, Abstract
- Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3.: Humphry, N. J., Wheatley, S. P., et al.; Biol. Open 7, (2018), Application(s): WB / Reactant(s): Human, Abstract
- Map1lc3b and Sqstm1 Modulated Autophagy for Tumorigenesis and Prognosis in Certain Subsites of Oral Squamous Cell Carcinoma.: Liu, P. F., Chang, H. W., et al.; J. Clin. Med. 7, (2018), Application(s): IHC / Reactant(s): Human, Abstract
- Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.: Meister-Broekema, M., Freilich, R., et al.; Nat. Commun. 9, 5342 (2018), Reactant(s): Human, Abstract
- Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1: Toledo, M., Batista-Gonzalez, A., et al.; Cell Metab. 28, 268 (2018), Abstract
- Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer: Yeo, S. K., Paul, R., et al.; Autophagy 14, 1214 (2018), Abstract
- Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans: Walters, R. O., Arias, E., et al.; Cell Rep. 25, 663 (2018), Abstract
- DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy: T.B. Nguyen, et al.; Dev. Cell 42, 9 (2017), Abstract — Full Text
- Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors: R. Iurlaro, et al.; Mol. Cell. Biol. 37, e00479 (2017), Application(s): ICC, IP, WB, Abstract — Full Text
- Helicobacter pylori CagA Protein Negatively Regulates Autophagy and Promotes Inflammatory Response via c-Met-PI3K/Akt-mTOR Signaling Pathway: N. Li, et al.; Front. Cell. Infect. Microbiol. 7, 417 (2017), Application(s): IHC / Reactant(s) Human, Abstract — Full Text
- Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy: F. Yue, et al.; Cancer Res. 77, 2938 (2017), Abstract — Full Text
- mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism: A. Lampada, et al.; Cell Death Diff. 24, 1045 (2017), Abstract — Full Text
- miR-130a Deregulates PTEN and Stimulates Tumor Growth: H. Wei, et al.; Cancer Res. 77, 6168 (2017), Application(s): WB in MEFs cell lysates, Abstract
- Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy: M.S. Kane, et al.; J. Cell. Mol. Med. 21, 2284 (2017), Application(s): WB / Reactant(s) Human, Abstract — Full Text
- Autophagy inhibition enhances antiproliferative effect of salinomycin in pancreatic cancer cells: S. Endo, et al.; Pancreatology 17, 990 (2017), Abstract
- Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target.: Vidal, M., Roth, F. P., et al.; Genome Res. 27, 1487 (2017), Application(s): WB / Reactant(s): Mouse, Abstract
- Feeding schedule and proteolysis regulate autophagic clearance of mutant huntingtin: Franciosi, S., Ladha, S., et al.; bioRxiv , (2017), Application(s): WB
- Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice: Endo, S., Nakata, K., et al.; Gastroenterology 152, 1492 (2017), Abstract
- Structural and functional analysis of the GABARAP interaction motif (GIM): Rogov, V. V., Stolz, A., et al.; EMBO Rep. 18, 1382 (2017), Abstract
- System-wide Benefits of Intermeal Fasting by Autophagy: Martínez-Lopez, N., Tarabra, E., et al.; Cell Metab. 26, 856 (2017), Abstract
- Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts: N. Yalamanchili, et al.; Front. Genet. 7, 171 (2016), Application(s): WB / Reactant(s) Human, Abstract — Full Text
- Atg5-dependent autophagy plays a protective role against methylmercury-induced cytotoxicity: Y. Takanezawa, et al.; Toxicol. Lett. 262, 135 (2016), Abstract
- Activation of Autophagy Contributes to the Angiotensin II-Triggered Apoptosis in a Dopaminergic Neuronal Cell Line: Q. Gao, et al.; Mol. Neurobiol. 53, 2911 (2016), Abstract
- Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice: S. Sukseree, et al.; PLoS One 11, e0161640 (2016), Application(s): Western blot analysis, RPE cell sheets, Abstract — Full Text
- Toll-like receptor 4 knockout alleviates paraquat-induced cardiomyocyte contractile dysfunction through an autophagy-dependent mechanism: S. Wang, et al.; Toxicol. Lett. 257, 11 (2016), Application(s): Western blot, Abstract
- Protein degradation in a LAMP-2 deficient B-lymphoblastoid cell line from a patient with Danon disease: R. Sanchez-Lanzas, et al.; Biochim. Biophys. Acta 1862, 1423 (2016), Application(s): Western blot, Abstract
- Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors: S. Kim, et al.; Sci. Rep. 6, 24933 (2016), Application(s): Cell culture, Abstract
- Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed: W. Li, et al.; Aging Cell 15, 370 (2016), Application(s): Immunoblotting / Reactant(s): Mouse, Abstract — Full Text
- Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury.: Kroemer, G., Blomgren, K., et al.; Autophagy 12, 410 (2016), Application(s): IHC, Abstract
- Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation.: Wang, L., Zhao, Y., et al.; Autophagy 11, 2160 (2016), Reactant(s): Human, Abstract
- Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.: Johansen, T., Layfield, R., et al.; Autophagy 12, 1094 (2016), Application(s): WB / Reactant(s): Human, Mouse, Abstract
- Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.: Gandhi, V., Ayres, M., et al.; Eur. J. Med. Chem. 123, 317 (2016), Reactant(s): Human, Abstract
- Autophagy confers resistance to lipopolysaccharide-induced mouse hepatocyte injury: Lalazar, G., Ilyas, G., et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 311, G377 (2016), Abstract
- Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient Mice: Kruszewski, K., Lüllmann-Rauch, R., et al.; Invest. Ophthalmol. Vis. Sci. 57, 1120 (2016), Abstract
- Potassium Bisperoxo (1,10-phenanthroline) Oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes: Q. Chen, et al.; J. Biol. Chem. 290, 26051 (2015), Abstract — Full Text
- Time-Point Dependent Activation of Autophagy and the UPS in SOD1G93A Mice Skeletal Muscle: S. Olivan, et al.; PLoS One 10, e0134830 (2015), Application(s): WB / Reactant(s): Mouse, Abstract — Full Text
- Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia: A.S. Watson, et al.; Cell Death Discov. 1, 15008 (2015), Application(s): Immunohistochemistry, Abstract — Full Text
- Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage: C. Park, et al.; Nat. Commun. 6, 6823 (2015), Application(s): Western Blot, Abstract
- Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice: B.K. Wong, et al.; Neurobiol. Dis. 76C, 24 (2015), Application(s): Western Blotting, Abstract
- Regulation of endoplasmic reticulum turnover by selective autophagy: A. Khaminets, et al.; Nature 522, 354 (2015), Abstract
- Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease: L. Zhou, et al.; Mol. Neurobiol. 52, 1180 (2015), Abstract
- Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function.: Norton, S., Haggarty, S. J., et al.; J. Biol. Chem. 290, 14361 (2015), Reactant(s): Human, Abstract
- Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation.: Macián, F., Botbol, Y., et al.; Autophagy 11, 1864 (2015), Application(s): WB / Reactant(s): Mouse, Abstract
- A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.: Ross, D., Siegel, D., et al.; Mol. Pharmacol. 88, 1045 (2015), Reactant(s): Human, Abstract
- Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients: Jiang, X., Zhong, W., et al.; Mol. Carcinog. 54, 1194 (2015), Abstract
- Measuring autophagy in stressed cells: Sharifi, M. N., Mowers, E. E., et al.; Methods Mol. Biol. 1292, 129 (2015), Abstract
- Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin: J. Zou, et al.; PLoS One 9, e94903 (2014), Application(s): WB of mouse cells, Abstract — Full Text
- p62/Sequestosome 1 Regulates Aggresome Formation of Pathogenic Ataxin-3 with Expanded Polyglutamine: L. Zhou, et al.; Int. J. Mol. Sci. 15, 14997 (2014), Application(s): WB and Fluoresecent Microscopy of human embryonic kidney cells (HEK293), Abstract — Full Text
- Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling: Y. Chen, et al.; J. Biol. Chem. 289, 1164 (2014), Application(s): WB of mouse tumor cells, Abstract
- Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons: H.H. Ryu, et al.; Neurobiol. Aging 35, 2822 (2014), Abstract
- BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch: M. Minoia, et al.; Autophagy 10, 1603 (2014), Abstract — Full Text
- p62/SQSTM1 synergizes with autophagy for tumor growth in vivo.: Guan, J. L., Croce, C. M., et al.; Genes Dev. 28, 1204 (2014), Application(s): WB, Abstract
- Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons.: Sapp, E., Difiglia, M., et al.; J. Biol. Chem. 289, 20845 (2014), Application(s): WB / Reactant(s): Mouse, Abstract
- Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity: Cicchini, M., Chakrabarti, R., et al.; Autophagy 10, 2036 (2014), Abstract
- ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss: Lozy, F., Cai-McRae, X., et al.; Autophagy 10, 662 (2014), Abstract
- Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein: S.M. Paine, et al.; PLoS One 8, e54711 (2013), Application(s): Immunohistochemistry of mouse tissue, Abstract — Full Text
- Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis: C. Droppelmann, et al.; Neurobiol. Aging 34, 248 (2013), Application(s): IHC of mouse spinal cord tissue, Abstract
- Proton-shuttling lichen compound usnic acid affects mitochondrial and lysosomal function in cancer cells: M. Bessadottir, et al.; PLoS One 7, e51296 (2013), Application(s): WB and IC of human cancer cells, Abstract — Full Text
- Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation: C. Manzoni, et al.; Biochem. Biophys. Res. Commun. 441, 862 (2013), Application(s): WB, IC of mutated human primary fibroblasts, Abstract — Full Text
- Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protects mice from diet-induced obesity and leads to degenerative lesions: D. Ma, et al.; J. Biol. Chem. 285, 39087 (2013), Application(s): WB, qPCR of mouse tissue, Abstract — Full Text
- Inhibition of nonsense-mediated RNA decay activates autophagy: J. Wengrod, et al.; Mol. Cell. Biol. 33, 2128 (2013), Application(s): WB of human mRNA, Abstract — Full Text
- Inhibition of LRRK2 kinase activity stimulates macroautophagy: C. Manzoni, et al.; Biochim. Biophys. Acta 1833, 2900 (2013), Application(s): WB of rat brain tissue, Abstract — Full Text
- Balance between autophagic pathways preserves retinal homeostasis: N. Rodríguez-Muela, et al.; Aging Cell 3, 478 (2013), Application(s): IF, PCR, WB of mouse retina, Abstract — Full Text
- Autophagy Is Induced by UVA and Promotes Removal of Oxidized Phospholipids and Protein Aggregates in Epidermal Keratinocytes: Y. Zhao, et al.; J. Invest. Dermatol. 133, 1629 (2013), Application(s): WB of mouse keratinocytes, Abstract — Full Text
- Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD: D. Ma, et al.; Mol. Endocrinol. 27, 1643 (2013), Application(s): WB of mouse hepatocytes, Abstract
- Angiotensin-(1-7) inhibits autophagy in the brain of spontaneously hypertensive rats: T. Jiang, et al.; Pharmacol. Res. 71, 61 (2013), Application(s): WB of rat brain tissue, Abstract
- Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy: V. Hernadnez-Gea, et al.; J. Hepatol. 59, 98 (2013), Abstract — Full Text
- Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro: L. Zhou, et al.; Acta Pharmacol. 34, 651 (2013), Abstract — Full Text
- Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability.: Yue, F., Li, W., et al.; Biochem. J. 454, 447 (2013), Application(s): WB / Reactant(s): Human, Abstract
- Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma.: Wang, L., Shen, Y., et al.; J. Hematol. Oncol. 6, 53 (2013), Application(s): WB, Abstract
- Glucose-starved cells do not engage in prosurvival autophagy.: Prehn, J. H., Ryan, K. M., et al.; J. Biol. Chem. 288, 30387 (2013), Application(s): WB, Abstract
- Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation: Liu, F., Fang, F., et al.; J. Bone Miner. Res. 28, 2414 (2013), Abstract
- Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues: V. Hernadnez-Gea, et al.; Gastroenterology 142, 938 (2012), Abstract — Full Text
- The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuole: I. Tattoli, et al.; Biol. Open 1, 1215 (2012), Application(s): WB, IF, qPCR of bacteria, Abstract — Full Text
- Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes: L. Chen, et al.; Acta Pharmacol. Sin. 33, 385 (2012), Application(s): WB of rat astrocytes , Abstract — Full Text
- Analysis of macroautophagy by immunohistochemistry: M. Rosenfeldt, et al.; Autophagy 8, 963 (2012), Application(s): WB, IHC of human and mouse tissues, Abstract — Full Text
- Heterozygosity for the proteasomal Psmc1 ATPase is insufficient to cause neuropathology in mouse brain, but causes cell cycle defects in mouse embryonic fibroblasts: N. Rezvani, et al.; Neurosci. Lett. 521, 130 (2012), Abstract
- Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model: S. Sukseree, et al.; PLoS One 7, e38933 (2012), Abstract — Full Text
- Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats.: Liu, Y., Guo, J., et al.; PLoS One 7, e46092 (2012), Application(s): WB / Reactant(s): Rat, Abstract
- Temporal orchestration of circadian autophagy rhythm by C/EBPβ: D. Ma, et al.; EMBO J. 30, 4642 (2011), Application(s): WB of mouse tissue, Abstract — Full Text
- Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.: Jäättelä, M., Daugaard, M., et al.; J. Biol. Chem. 286, 38904 (2011), Application(s): WB / Reactant(s): Human, Abstract
- Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis.: Xie, R., Wang, F., et al.; Cancer Res. 71, 7537 (2011), Reactant(s): Mouse, Abstract
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