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p53 monoclonal antibody (PAb421)

BML-SA293

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PAb421 antibody induces allosteric changes in certain tumor-derived p53 mutants and restores tumor suppressor activity. Microinjection of PAb421 into SW480 colorectal carcinoma cells restored transcriptional activation function to the resident mutant p53 (Arg to His 273, Pro to Ser 309). The epitope for PAb421 is contained within the “p53 activator peptide” 46. Thus the antibody recognizes this peptide and has been used to examine cellular uptake of the p53 activator peptide.

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Product Details

Alternative Name	TRP53, Tumor protein p53
Application	ICC, IHC, IP, WB
Clone	PAb421
Formulation	Liquid. In 50 mM sodium phosphate buffer, pH 7.5, containing 0.2% gelatin and 0.09% sodium azide.
Host	Mouse
Immunogen	Synthetic peptide corresponding to aa 371-380 of human p53.
Isotype	IgG2a
Purity Detail	Purified.
Recommendation Dilutions/Conditions	Western Blot (10µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse, Rat
UniProt ID	P04637
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence: Salazar, G., Cullen, A., et al.; Autophagy 16, 1092 (2020), Abstract
p53 and Mdm2 act synergistically to maintain cardiac homeostasis and mediate cardiomyocyte cell cycle arrest through a network of microRNAs.: Backx, P. H., Mak, T. W., et al.; Cell Cycle 16, 1585 (2017), Application(s): WB / Reactant(s): Mouse, Abstract
Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death.: Mak, T. W., Hauck, L., et al.; PLoS One 12, e0189861 (2017), Application(s): IP, WB / Reactant(s): Mouse, Abstract
Direct α-synuclein promoter transactivation by the tumor suppressor p53: Duplan, E., Giordano, C., et al.; Mol. Neurodegener. 11, 13 (2016), Abstract
Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability.: Toyoda, M., Fukawatase, Y., et al.; Sci. Rep. 4, 5421 (2014), Application(s): WB, Abstract
Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination: J. Kawada, et al.; Int. J. Cancer 130, 584 (2012), Application(s): WB, Abstract — Full Text
miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress: J. Xiao, et al.; EMBO J. 30, 5021 (2011), Abstract
Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site: R.D. Kirschner, et al.; Nucleic Acids Res. 36, 2969 (2008), Application(s): Used for electrophoretic mobility shift assay (EMSA), Abstract — Full Text

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p53 monoclonal antibody (PAb421)

BML-SA293

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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