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p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to Mdm2, SV40 T antigen and human Papilloma virus E6 protein. p53 senses DNA damage and facilitates its repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovary, bladder, colon, lung, and melanoma.
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Western blot analysis of p53: Lane 1: MW marker, Lane 2: A431, Lane 3: rat brain, Lane 4: mouse brain.
Endometrial carcinoma stained by immunohistochemistry with p53 monoclonal antibody (PAb122) (ENZ-ABS849, 1:20 Dilution).
Endometrial carcinoma stained by immunohistochemistry with p53 monoclonal antibody (PAb122) (ENZ-ABS849, 1:20 Dilution).
Flow cytometry analysis of 10^6 Jurkat cells stained using p53 monoclonal antibody (PAb122), (Prod. No. ENZ-ABS849), at a concentration of 50 µg/mL.
| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Application | ELISA, IHC, WB |
|---|---|
| Host | Goat |
| Species Reactivity | Mouse |
| Alternative Name | TRP53, Tumor protein p53 |
|---|---|
| Purity | ≥90% (SDS-PAGE) |
| Source | Produced in E. coli. |