P505-15

P505-15 is a highly selective and potent inhibitor of spleen tyrosine kinase (Syk). It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models. It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis. P505-15 was also found to inhibit PINK1 in HeLa cells and dopaminergic neurons.