P32/98

BML-PI142

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DPPIV/DPP4 inhibitor

P32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a K_i of 130 nM. Useful in diabetes research. Has been used in vivo and in tissue culture.

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Product Details

Alternative Name	3-N-[((2S,3S)-2-Amino-3-methylpentanoyl]-1,3-thiazolidine . hemi-fumarate
Appearance	White solid.
Application Notes	May be used to inhibit GLP-1 breakdown in blood, plasma and serum samples at a concentration of 1 mM.
CAS	136259-20-6
Couple Target	DPP
Couple Type	Inhibitor
Formula	C₉H₁₈N₂OS . 0.5 C₄H₄O₄
MW	260.4
Purity	≥98% (TLC, free base)
Solubility	Soluble in water (20mg/ml) or DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Development of a 13C Stable Isotope Assay for Dipeptidyl Peptidase-4 Enzyme Activity A New Breath Test for Dipeptidyl Peptidase Activity: Yazbeck, R., Jaenisch, S., et al.; Sci. Rep. 9, 4906 (2019), Abstract
Dipeptidyl peptidase IV inhibition upregulates GLUT4 translocation and expression in heart and skeletal muscle of spontaneously hypertensive rats: G. Giannocco, et al.; Eur. J. Pharmacol. 698, 74 (2013), Application(s): Assay using rat skeletal and heart muscle, Abstract
Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1: R. Crajoinas, et al.; Am. J. Physiol. Renal Physiol. 301, F355 (2011), Application(s): Assay using rat urine and blood, Abstract — Full Text
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats: J.A. Pospisilik, et al.; Diabetes 52, 741 (2003), Application(s): Oral gavage, Abstract — Full Text
Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats: J.A. Pospisilik, et al.; Diabetes 51, 943 (2002), Application(s): Oral gavage, Abstract — Full Text

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P32/98

BML-PI142

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