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P22077 is a cell-permeable inhibitor of the ubiquitin-specific protease USP7 (IC50 = 8.6 μM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 > 50 μM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20-40 μM) causes an accumulation of K48-linked ubiquitinated species, and downregulation of the USP7 targets HDM2 and claspin.
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