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Oxatomide

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Inhibits the release and actions of leukotrienes

Suppresses PAF-induced bronchoconstriction in the guinea pig (ED₅₀=0.9 mg/kg orally).

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Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Suppression of PAF-induced bronchoconstriction in the guinea-pig by oxatomide: mechanism of action: F. P. Nijkamp, et al.; Naunyn-Schmeideberg’s Arch. Pharmacol. 340, 111 (1989), Abstract
Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung: Y. Kosaka, et al.; Agents Actions 21, 32 (1985), Abstract
Inhibitory effects of oxatomide on several activities of SRS-A and synthetic leukotrienes in guinea-pigs and rats: K. Ohmori, et al.; Arch. Int. Pharmacodyn. Ther. 275, 139 (1985), Abstract
Oxatomide. A review of its pharmacodynamic properties and therapeutic efficacy: D. M. Richards, et al.; Drugs 27, 210 (1984), Abstract

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