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Ouabain . octahydrate

ALX-350-066

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Na⁺/K⁺ ATPase inhibitor

A steroidal inhibitor of cardiac sodium pumps (Na⁺/K⁺ ATPase) which has been recognized as an endogenous adrenal hormone. In the CNS it can be used as a tool to induce in vivo excitotoxicity. Ouabain, as well as other endogenous digitalis-like compounds, can down-regulate the expression of 14-3-3 proteins in rat lens.

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Product Details

Alternative Name	Strophanthin G, 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α-14,19-penta-hydroxycard-20(22)-enolide
Appearance	White solid.
CAS	11018-89-6
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₂₉H₄₄O₁₂ . 8H₂O
MI	14: 6901
MW	584.6 . 144.2
Purity	≥98% (TLC)
Solubility	Soluble in water (>25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation: Y. Hovhannisyan, et al.; Stem Cell Res. Ther. 15, 10 (2024), Abstract
ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel: R.J. Kathawala, et al.; Chin. J. Cancer 34, 5 (2015), Application(s): Cell Culture, Abstract — Full Text
Anti-inflammatory and antinociceptive activity of ouabain in mice: D.I. de Vasconcelos, et al.; Mediators Inflamm. 2011, 912925 (2011), Abstract — Full Text
Na+,K+-ATPase and hormone ouabain:new roles for an old enzyme and an old inhibitor: R.G. Contreras, et al.; Cell. Mol. Biol. 52, 31 (2006), (Review), Abstract
Vascular endothelium as a target for endogenous ouabain: studies on the effect of ouabain on human endothelial cells: L. Trevisi, et al.; Cell. Mol. Biol. 52, 64 (2006), (Review), Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005), Abstract
Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases: W.B. Veldhuis, et al.; J. Neurosci. 23, 4127 (2003), Abstract
Endogenous cardiac glycosides, a new class of steroid hormones: W. Schoner; Eur. J. Biochem. 269, 2440 (2002), Abstract
The cardiac sodium pump: structure and function: A.A. McDonnough, et al.; Basic Res. Cardiol. 97 Suppl1, I19 (2002), Abstract
Digitalis and digitalislike compounds down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens: D. Lichtstein, et al.; Hypertens. Res. 23 Suppl., S51 (2000), Abstract

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Ouabain . octahydrate

ALX-350-066

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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