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Oridonin

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Antitumor agent

Diterpene with potent anti-tumor activity. Induces apoptosis and autophagy.

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Alternative Name	Isodonol
Appearance	White to off-white powder.
CAS	28957-04-2
Formula	C₂₀H₂₈O₆
MW	364.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (20mg/ml) or PEG 400; insoluble in water.
Source	Isolated from Rabdosia rubescens

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells: Y. Cheng et al.; Autophagy 5, 430 (2009), Abstract
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways: T. Ikezoe, et al.; Mol. Cancer Ther. 4, 578 (2005), Abstract
Apoptotic effect of oridonin on NB4 cells and its mechanism: J. Liu, et al.; Leuk. Lymphoma 46, 593 (2005), Abstract
Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells: T. Ikezoe, et al.; Int. J. Oncol. 23, 1187 (2003), Abstract

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