ORG-12962

BML-NS705

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Serotonin receptor activator

Selective serotonin 5-HT_2C agonist. Displays antiaversive effects in a panic-like anxiety rat model. May display appetite regulating properties similar to other 5-HT_2C agonists.

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Product Details

Alternative Name	1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine
Appearance	Pale yellow solid.
CAS	210821-63-9
Couple Target	Serotonin receptor
Couple Type	Activator, Ligand
Formula	C₁₀H₁₁ClF₃N₃
Identity	Determined by 1H-NMR.
MW	265.7
Purity	≥95% (NMR)
Solubility	Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity: J.C. Halford, et al.; Curr. Drug Targets 6, 201 (2005), Abstract
Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells: R.H. Porter, et al.; Br. J. Pharmacol. 128, 13 (1999), Abstract
Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats: F. Jenck, et al.; Eur. Neuropsychopharmacol. 8, 161 (1998), Abstract

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ORG-12962

BML-NS705

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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