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Orexin A (human, bovine, rat, mouse)

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Food intake modulator

Hypothalamic neuropeptide that stimulates food intake in rats with impressive potency. Binds specifically to the OX₁ receptor.

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Formula	C₁₅₂H₂₄₃N₄₇O₄₄S₄
Formulation	Lyophilized.
MW	3561.2
Peptide Content	70-90%
Purity	≥98% (HPLC)
Sequence	Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH₂ (Disulfide bonds between Cys⁶-Cys¹² and Cys⁷-Cys¹⁴).
Solubility	Soluble in DMSO; can be diluted with buffers or distilled water.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Orexins and orexin receptors: a family of hypotalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour: T. Sakurai, et al.; Cell 92, 573 (1998), Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger: M.W. Schwartz; Nature Medicine 4, 385 (1998), Abstract

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