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Ophiobolin A

ALX-270-109

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Calmodulin antagonist. PDE inhibitor.

Cell permeable antagonist of calmodulin. Inhibits Ca²⁺/calmodulin-dependent phosphodiesterase. Inhibits P-glycoprotein-mediated transport. Exhibits antibacterial, antitumor and nematocidal activities. Phytotoxic.

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Product Details

Alternative Name	Cochliobolin A, Ophiobalin
Appearance	White to off-white solid.
CAS	4611-05-6
Couple Target	PDE
Couple Type	Inhibitor
Formula	C₂₅H₃₆O₄
MW	400.6
Purity	≥95% (HPLC)
RTECS	RL1576000
Solubility	Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol.
Source	Isolated from Bipolaris leersia MST-FP107.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Remodelling of Ca 2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells: T. Pick, et al.; Cell Calcium 99, 102473 (2021), Abstract
The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine: C. Chidley, et al.; eLife 5, e14601 (2016), Application(s): Reagent, used to assess cytotoxicity effects, Abstract — Full Text
Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products: N. Yoshida, et al.; Food Chem. Toxicol. 44, 2033 (2006), Abstract
Herbicidal potential of ophiobolins produced by Drechslera gigantea: A. Evidente, et al.; J. Agric. Food Chem. 54, 1779 (2006), Abstract
Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis: S. Quetglas, et al.; EMBO J. 21, 3970 (2002), Abstract — Full Text
The biology of ophiobolins: T.K. Au, et al.; Life Sci. 67, 733 (2000), Review, Abstract
Microbial metabolites of ophiobolin A and antimicrobial evaluation of ophiobolins: E. Li, et al.; J. Nat. Prod. 58, 74 (1995), Abstract
Characterization of the interaction of ophiobolin A and calmodulin: P.C. Leung, et al.; Int. J. Biochem. 20, 1351 (1988), Abstract
Role of Calmodulin Inhibition in the Mode of Action of Ophiobolin A: P.C. Leung, et al.; Plant Physiol. 77, 303 (1985), Abstract — Full Text
Ophiobolin A. A natural product inhibitor of calmodulin: P.C. Leung, et al.; J. Biol. Chem. 259, 2742 (1984), Abstract — Full Text

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Ophiobolin A

ALX-270-109

Product Details

Handling & Storage

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