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ONO-RS-082

BML-ST320

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Phospholipase inhibitor

Phospholipase A₂ inhibitor (IC₅₀=7 µM for purified guinea pig lung PLA₂). Inhibits epinephrine-stimulated thromboxane production in human platelets (86% at 3.5µM). Also blocks insulin secretion in pancreatic islets in response to glucose. Disrupts membrane tubule-mediated reassembly and maintenance of the Golgi complex.

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Product Details

Alternative Name	2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid
Appearance	Off-white to yellow solid.
CAS	99754-06-0
Couple Target	Phospholipase, PLA
Couple Type	Inhibitor
Formula	C₂₁H₂₂ClNO₃
MW	371.9
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml, warm) or 100% ethanol (10mg/ml, warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 2 years after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light. Do not freeze.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Neutrophil-Derived Cytosolic PLA2α Contributes to Bacterial-Induced Neutrophil Transepithelial Migration: Yonker, L. M., Pazos, M. A., et al.; J. Immunol. 199, 2873 (2017), Abstract
Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex: R. Abu-Hamdah, et al.; Cell Biol. Int. 28, 7 (2004), Abstract
Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists: P. de Figueiredo, et al.; Mol. Biol. Cell 10, 1763 (1999), Abstract
Inhibition of phospholipase A2 and insulin secretion in pancreatic islets: R.J. Konrad, et al.; Biochim. Biophys. Acta 1135, 215 (1992), Abstract
Effect of phospholipase A2 inhibitor ONO-RS-082 on substance P-induced histamine release from rat peritoneal mast cells: M. Kurosawa, et al.; Int. Arch. Allergy Immunol. 97, 226 (1992), Abstract
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine: H.S. Banga, et al.; PNAS 83, 9197 (1986), Abstract

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ONO-RS-082

BML-ST320

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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