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OMNICATHEPSIN^® fluorogenic substrate

BML-P139

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Fluorogenic substrate cleaved by plasma kallikrein and kallikrein 8, but not plasmin; by papain; and by most cathepsins (cathepsins B, C/DPP-I, F, K/O2, L, L2/V, O, S, and X/Z). Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

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Product Details

Alternative Name	Z-FR-AMC, Z-Phe-Arg-AMC
CAS	65147-22-0
Formula	C₃₃H₃₆N₆O₆ . HCl
MW	649.2
Purity	≥99%
Sequence	Z-FR-AMC, Z-Phe-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models: Drobny, S., Boros, F. A., et al.; Transl. Neurodegener. 12, 31 (2023), Abstract
Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome: M.C. McKelvey, et al.; Am. J. Respir. Crit. Care Med. 1164, 1631OC (2022), Abstract
Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes: S. Gumeni, et al.; Cell Death Dis. 12, 41419 (2021), Abstract
Modulation of Cystatin C in Human Macrophages Improves Anti-Mycobacterial Immune Responses to Mycobacterium tuberculosis Infection and Coinfection With HIV: D. Pires, et al.; Front. Immunol. 18, 742822 (2021), Abstract
Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules: K. Georgousaki, et al.; Molecules 25, 666 (2020), Application(s): Cathepsin B, L enzymatic activity in human foreskin fibroblasts (BJ) lysates., Abstract — Full Text
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract
Skeletal Muscle Lysosomal Function via Cathepsin Activity Measurement: K. Gumpper, et al.; Methods Mol. Biol. 1854, 35 (2019), Abstract
Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply: H. Zhang, et al.; Autophagy 14, 1779 (2018), Abstract
Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs: J. Vallecillo-Hernandez, et al.; Sci. Rep. 8, 3593 (2018), Abstract — Full Text
Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients: C. Valdez, et al.; Hum. Mol. Genet. 26, 4861 (2017), Abstract — Full Text

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OMNICATHEPSIN^® fluorogenic substrate

BML-P139

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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