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Oligomycin C

ALX-380-039

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F-ATPase inhibitor

Minor component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F₁F₀), preventing phosphoryl group transfer. Induces apoptosis.

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Product Details

Alternative Name	12-Deoxyoligomycin A
Appearance	White to off-white powder.
CAS	11052-72-5
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₄₅H₇₄O₁₀
MI	14: 6833
MW	775.1
Purity	≥95% (HPLC)
RTECS	RK3335000
Solubility	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Source	Isolated from Streptomyces sp. MST-AS5339.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004), Abstract
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002), Abstract — Full Text
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000), Abstract — Full Text
Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Engr. 2, 31 (1960), Abstract

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Oligomycin C

ALX-380-039

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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