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Oligomycin A

BML-CM111

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ATPase inhibitor

Inhibits mitochondrial ATPases (F₁F₀). Stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Induces autophagy in the IPLB-LdFB insect cell line.

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Product Details

Appearance	White solid.
CAS	579-13-5
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₄₅H₇₄O₁₁
MI	14: 6833
MW	791.1
Purity	≥97% (HPLC, TLC)
RTECS	RK3328000
Solubility	Soluble in DMSO (300mg/ml), 100% ethanol (200mg/ml) or acetone (800mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome: I.A. Khatib, et al.; J. Biol. Chem. 298, 102420 (2022), Abstract
Functional regulation of 4D metabolic network between multienzyme glucosome condensates and mitochondria: Kennedy, E. L., Jeon, M., et al.; bioRxiv , (2022)
NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling: Szczepanski, H. E., Flannigan, K. L., et al.; FASEB J. 36, e22609 (2022), Abstract
Unique metabolic phenotype and its transition during maturation of juvenile male germ cells: A.L. Voigt, et al.; FASEB J. 35, 21513 (2021), Abstract
Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells: W.F. Alpaugh, et al.; Cells 10, 2265 (2021), Abstract
Oligomycin A induces autophagy in the IPLB-LdFB insect cell line: G. Tettamanti, et al.; Cell Tissue Res. 326, 179 (2006), Abstract
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004), Abstract
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002), Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000), Abstract
Acidification of rat liver lysosomes: quantitation and comparison with endosomes: R.W. Van Dyke; Am. J. Physiol. 265, C901 (1993), Abstract

Last modified: May 29, 2024

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Oligomycin A

BML-CM111

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