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Oligomycin

ALX-380-037

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F-ATPase inhibitor

Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F₁), preventing phosphoryl group transfer. Induces apoptosis.

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Product Details

Appearance	White to faint yellow powder.
CAS	1404-19-9
Couple Target	ATPase
Couple Type	Inhibitor
MI	14: 6833
MW	791.1 (Oligomycin A)
Purity	≥90% (HPLC, TLC)
Purity Detail	Mixture of oligomycin A (major component), B, and C.
RTECS	RK3325000
Solubility	Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml).
Source	Isolated from Streptomyces diastatochromogens.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts: D.M. Booth, et al.; STAR Protoc. 3, 101119 (2022), Abstract — Full Text
Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER: D.M. Booth, et al.; Mol. Cell 81, 3866 (2021), Abstract — Full Text
Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics: A. Klusoczki, et al.; Sci. Rep. 9, 5823 (2019), Abstract — Full Text
Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen: M. Deygas, et al.; Nat. Commun. 9, 4545 (2018), Abstract — Full Text
UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy: A.C. Bento, et al.; Sci. Rep. 8, 12415 (2018), Abstract — Full Text
Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury: R.L. Hill, et al.; Neurochem. Int. 111, 45 (2017), Abstract
Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines: Koss, B., Ryan, J., et al.; Oncotarget 7, 11500 (2016), Abstract
The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions: S. Koob, et al.; Biochim. Biophys. Acta 1853, 1551 (2015), Application(s): Cell Culture, Abstract
Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions: R. Dawaliby, et al.; Mol. Biol. Cell 21, 4173 (2010), Abstract — Full Text
Properties of DNA fragmentation activity generated by ATP depletion: N. Nakamura & Y. Wada; Cell Death Differ. 7, 477 (2000), Abstract

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Oligomycin

ALX-380-037

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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