Olig-2 recombinant monoclonal antibody (064)

The anti-Olig2 antibody is a reliable tool for detecting human Olig2, a basic helix-loop-helix transcription factor crucial for the development and maintenance of oligodendrocytes and motor neurons.

Olig-2 plays a key role in the specification and differentiation of oligodendrocytes and motor neurons in the central nervous system (CNS). Olig-2 is essential for the formation of myelin-producing oligodendrocytes, which are vital for proper neuronal function and axonal insulation. In neurodevelopment, Olig-2 regulates neural progenitor proliferation and lineage specification, while in disease contexts, it is associated with gliomas, particularly oligodendrogliomas, where it serves as a diagnostic marker. Olig-2’s involvement in CNS injury and repair also highlights its importance in neurodegeneration and regenerative medicine.