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Okadaol

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Derived from okadaic acid by reduction of the carboxyl group. Inactive against protein phosphatases.

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Appearance	Colorless solid.
CAS	131959-12-1
Formula	C₄₄H₇₀O₁₂
MW	791.1
Purity	≥90%
Solubility	Soluble in methanol or DMSO.
Source	Semisynthetic derivative of okadaic acid. Okadaic acid isolated from Prorocentrum lima.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The total activity of a mixture of okadaic acid-group compounds can be calculated by those of individual analogues in a phosphoprotein phosphatase 2a assay: C. Albano, et al.; Toxicon 53, 631 (2009), Abstract
Regulation of immunoglobulin E-mediated secretion by protein phosphatases in human basophils and mast cells of skin and lung: R. Bastan, et al.; Eur. J. Pharmacol. 430, 135 (2001), Abstract
Preliminary characterization of the role of protein serine/threonine phosphatases in the regulation of human lung mast cell function: M.J. Peirce, et al.; Br. J. Pharmacol. 120, 239 (1997), Abstract
An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures: J.S. Sidhu & C.J. Omiecinski; J. Pharmacol. Exp. Ther. 282, 1122 (1997), Abstract
Regulation of human basophil function by phosphatase inhibitors: M.J. Peirce, et al.; Br. J. Pharmacol. 119, 446 (1996), Abstract
Characterization of natural toxins with inhibitory activity against serine/threonine protein phosphatases: R.E. Honkanen, et al.; Toxicon 32, 339 (1994), Abstract
Regulation of human lung mast cell function by phosphatase inhibitors: P.T. Peachell & M.R. Munday; J. Immunol. 151, 3808 (1993), Abstract

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