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Okadaic acid . sodium salt (high purity)

ALX-350-011

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Inhibitor of PP1 and PP2A

Salt form of okadaic acid (Prod. No. ALX-350-003), with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). Potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Potent tumor promotor and neurotoxin.

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Product Details

Alternative Name	Halochondrine A . Na, 9,10-Deepithio-9,10-didehydroacanthifolicin . Na
Appearance	White to off-white solid.
CAS	209266-80-8
Couple Target	Serine/threonine-protein phosphatase
Couple Type	Inhibitor
Formula	C₄₄H₆₇O₁₃ . Na
MW	804.0 . 23.0
Purity	≥98% (TLC)
Solubility	Soluble in ethanol or methanol.
Source	Isolated from Prorocentrum Sp.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

MDM2 functions as a timer reporting the length of mitosis: Fulcher, L. J., Sobajima, T., et al.; Nat. Cell Biol. 27, 262 (2025), Abstract
WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer: Sobajima, T., Fulcher, L. J., et al.; EMBO J. 44, 4378 (2025), Abstract
Proteomic analysis of hepatic effects of okadaic acid in HepaRG human liver cells: L.T.D. Wuerger, et al.; EXCLI J. 22, 1135 (2023), Abstract
MDM2 acts as a timer reporting the length of mitosis: Fulcher, L. J., Sobajima, T., et al.; bioRxiv , (2023)
PP6-regulated Aurora A activity towards NDC80 limits mitotic spindle size to prevent micronucleation: Sobajima, T., Kowalczyk, K. M., et al.; bioRxiv , (2022)
Evidence for functional selectivity in TUDC- and norUDCA-induced signal transduction via α5β1 integrin towards choleresis: M. Bonus, et al.; Sci. Rep. 10, 5795 (2020), Abstract — Full Text
Selection and identification of DNA aptamers against okadaic acid for biosensing application: S. Eissa, et al.; Anal. Chem. 85, 11794 (2013), Abstract
A graphene-based electrochemical competitive immunosensor for the sensitive detection of okadaic acid in shellfish: S. Eissa, et al.; Nanoscale 4, 7593 (2012), Abstract