ODQ

ALX-270-034

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Guanylyl cyclase inhibitor

ODQ is a potent and selective, direct-acting inhibitor of guanylate cyclase (IC₅₀=20 nM). In cerebellar slices ODQ reversibly inhibited cGMP generation in response to endogenous NO or exogenously added NO-donors. ODQ does not inhibit NO-mediated macrophage toxicity (a phenomenon unrelated to cGMP) and does not inhibit particulate guanylyl cyclase or adenylyl cyclase. ODQ is an unique and selective tool to elucidate the physiological importance of the NO-cGMP pathway.

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Product Details

Appearance	Off-white to yellow powder.
CAS	41443-28-1
Couple Target	Guanylyl cyclase
Couple Type	Inhibitor
Formula	C₉H₅N₃O₂
MW	187.2
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (5mg/ml), ethyl acetate or 100% ethanol (1.2mg/ml); insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions may decompose slowly.
Handling	Protect from light.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties: M. Saletti, et al.; Eur. J. Med. Chem. 241, 114615 (2022), Abstract
Fermented garlic extract decreases blood pressure through nitrite and sGC-cGMP-PKG pathway in spontaneously hypertensive rats: B.M. Park, et al.; J. Funct. Foods 22, 156 (2016), Application(s): Cell culture
Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling: Lindsey, S. H., Liu, L., et al.; Steroids 81, 99 (2014), Abstract
Changes in nerve-mediated contractility of the lower urinary tract in a mouse model of premature ageing: Triguero, D., Lafuente-Sanchis, A., et al.; Br. J. Pharmacol. 171, 1687 (2014), Abstract
Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice: E.P. Schmidt, et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 295, (2008), Abstract
Interstitial cells of Cajal in the urethra are cGMP-mediated targets of nitrergic neurotransmission: García-Pascual, A., Sancho, M., et al.; Am. J. Physiol. Renal Physiol. 295, F971 (2008), Abstract
Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury: Duranski, M. R., Elrod, J. W., et al.; Am. J. Physiol. Heart Circ. Physiol. 291, H2980 (2006), Abstract
Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery: involvement of nitric oxide and an additional unidentified neurotransmitter: Overend, J., Wilson, W. S., et al.; Br. J. Pharmacol. 145, 1001 (2005), Abstract
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem. 275, 13613 (2000), Abstract — Full Text
Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea: T.L. Hwang, et al.; Br. J. Pharmacol. 125, 1158 (1998), Abstract

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Last modified: May 29, 2024

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ODQ

ALX-270-034

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