ODN 2395 (TLRGRADE®) (synthetic) (BULK)

TLR, TLR9

Activator, Ligand

<0.002 EU/µg (LAL test; BioWhittaker)

Lyophilized. Sterile.

7068 (ammonium salt)

Activity and endotoxin tested – TLRGRADE®.

143nmol (~1’000µg).

For a 100µM stock solution, dissolve the total vial content in 1430µl endotoxin-free ddWater (Prod. No. ALX-505-008; included) or endotoxin-free PBS (Prod. No. ALX-505-007; order separately). To obtain optimal dissolving we recommend the following procedure:- Add 50% of the solvent and let dissolve for 10 min.- Add remaining 50% of the solvent and mix thoroughly.- Moderate warming may aid dissolving.

5’-tcgtcgttttcggcgcgcgccg-3’(bold letters indicate active, immune-stimulatory portions of CpG sequence, un-bolded letters indicate phosphorothioate linkage)

Synthetic.

Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).
For the inactive control compound, please see Prod. No. ALX-746-256.