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ODN 2395 (TLRGRADE^®) (synthetic)

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TLR9 ligand

CpG oligodeoxynucleotide (Type C) with phosphorothioate backbone. Specific ligand for human and mouse TLR9 (Toll-like receptor 9).

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Couple Target	TLR, TLR9
Couple Type	Ligand
Endotoxin Content	<0.002 EU/µg (LAL test; BioWhittaker)
Formulation	Lyophilized. Sterile.
MW	7068 (ammonium salt)
Purity Detail	Activity and endotoxin tested – TLRGRADE®.
Sequence	5’-tcgtcgttttcggcgcgcgccg-3’(bold letters indicate active, immune-stimulatory portions of CpG sequence, un-bolded letters indicate phosphorothioate linkage)
Source	Synthetic.
Technical Info / Product Notes	Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008). For the inactive control compound, please see Prod. No. ALX-746-256.

Use/Stability	As indicated on product label or CoA when stored as recommended. Aqueous stock solution is stable for 1 day when stored at +4°C.
Handling	Protect from light. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity: M. Peiser, et al.; J. Leukoc. Biol. 83, 1118 (2008), Abstract