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CpG oligodeoxynucleotide (Type B) with phosphorothioate backbone. Specific ligand for mouse TLR9 (Toll-like receptor 9).
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Figure 2: TLR9-dependent mitogenic activity of ODN 1668 (TLRGRADE®) (synthetic) (Prod. No. ALX-746-001) in mouse splenocytes. Method: Culture of 5×105 cells per 200µl well was performed in serum-free conditions after addition of ODNs at the indicated concentrations. Cell proliferation was analyzed after 72 hours with a 16 hours3H-thymidine pulse.Only CpG ODN 1668 (Prod. No. ALX-746-001)
Figure 1: TLR9-dependent activation of mouse macrophages by ODN 1668 (TLRGRADE®) (synthetic) (Prod. No. ALX-746-001). Method: Culture of 5×105 cells per 200µl well was performed in serum-free conditions after addition of ODNs at the indicated concentrations. Cell activation was measured by IL12-p40 induction. Only CpG ODN 1668 (Prod. No. ALX-746-001)
| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | CpG-B |
|---|---|
| Couple Type | Ligand |