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Ochratoxin A

ALX-630-089

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Mycotoxin. Nephrotoxic.

Mycotoxin. Natural contaminant of mouldy food and feed. It has a number of toxic effects, the most prominent being nephrotoxicity. Immunosuppressive, genotoxic, teratogenic and carcinogenic. Stimulates lipid peroxidation. Induces oxidative DNA lesions coupled with direct DNA adducts via quinone formation.

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Product Details

Appearance	White to off-white crystalline powder.
CAS	303-47-9
Formula	C₂₀H₁₈ClNO₆
MI	14: 6740
MW	403.8
Purity	≥98% (HPLC, TLC)
RTECS	AY4375000
Solubility	Soluble in methanol (10mg/ml).
Source	Isolated from Aspergillus ochraceus.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Ochratoxin A-enhanced glycolysis induces inflammatory responses in human gastric epithelium cells through mTOR/HIF-1α signaling pathway: Y. Wang, et al.; Ecotoxicol. Environ. Saf. 270, 115868 (2024), Abstract
Electrochemical Aptamer-Based Sensors for Rapid Point-of-Use Monitoring of the Mycotoxin Ochratoxin A Directly in a Food Stream: J. Somerson, et al.; Molecules 23, 912 (2018), Abstract — Full Text
In vitro selection of an XNA aptamer capable of small-molecule recognition: A.E. Rangel, et al.; Nucleic Acids Res. 46, 8057 (2018), Abstract — Full Text
Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response: Fribley, A. M., Cruz, P. G., et al.; J. Biomol. Screen. 16, 825 (2011), Abstract
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans: A. Pfohl-Leszkowicz & R. A. Manderville; Mol. Nutr. Food Res. 51, 61 (2007), (Review), Abstract
Toxicokinetics and toxicodynamics of ochratoxin A, an update: D. Ringot, et al.; Chem. Biol. Interact. 159, 18 (2006), (Review), Abstract
How aspartame prevents the toxicity of ochratoxin A: E.E. Creppy, et al.; J. Toxicol. Sci. 23 Supp. 2, 165 (1998), Abstract
Toxicity and metabolism of ochratoxin A: J. Fink-Gremmels, et al.; Nat. Toxins 3, 214 (1995), Abstract
Effect of superoxide dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats: I. Baudrimont, et al.; Toxicology 89, 101 (1994), Abstract
Role of cytochrome P-450 in ochratoxin A-stimulated lipid peroxidation: R.F. Omar, et al.; J. Biochem. Toxicol. 6, 203 (1991), Abstract

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Ochratoxin A

ALX-630-089

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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