O(6)-Methylguanine-DNA Methyltransferase (MGMT) monoclonal antibody

This antibody stains all mantle zone lymphocytes and 50% of germinal center lymphocytes. Basaloid epithelial cells of tonsil squamous mucosa are also stained positive with this antibody.

MGMT, or O-6-methylguanine-DNA methyltransferase, is a crucial enzyme involved in DNA repair mechanisms within cells. Its primary function is to remove alkyl groups from the O-6 position of guanine, a common site of DNA damage induced by alkylating agents. By repairing this type of DNA damage, MGMT plays a vital role in maintaining genomic stability and protecting cells from the harmful effects of mutagenesis and carcinogenesis.