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NVP-TNKS657 is a potent and selective inhibitor of tankyrase enzymes, specifically targeting TNKS2 (IC50 value of 6 nM). It exhibits over 300-fold selectivity against PARP1 and PARP2, making it directly applicable for research focused on the Wnt/β-catenin signaling pathway.
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| Regulatory Status |
RUO – Research Use Only |
|---|
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| CAS | 38966-21-1 |
|---|---|
| Couple Type | Inhibitor |
| Purity | ≥98% (TLC) |
| Alternative Name | 6-(6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6,8-dihydrofuro[3,4-E][1,3]benzodioxol-8-ol, (+)-Decumbensine |
|---|---|
| CAS | 6883-44-9 |
| Purity | ≥98% (HPLC) |
| Alternative Name | (3S,3aR,4R,4aS,8aR,9aS)-4-[(1E)-2-[(2R,6S)-1,6-Dimethyl-2-piperdinyl]ethenyl]decahydro-3-methyl-naphtho[2,3-c]furan-1(3H)-one |
|---|---|
| CAS | 6879-74-9 |
| Couple Type | Inhibitor |
| Purity | ≥98% |
