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Inhibitor of p53/MDM2 interaction

(+/-) -Nutlin-3 is an inhibitor of p53/MDM2 interaction (IC₅₀=0.09µM).

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Alternative Name	(±)-4-[4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-piperazin-2-one
Appearance	White to off-white crystalline solid.
CAS	548472-68-0
Formula	C₃₀H₃₀Cl₂N₄O₄
MW	581.5
Purity	≥98% (HPLC (UV))
Solubility	Soluble in methanol, 100% ethanol, DMSO, dimethyl formamide or acetonitrile; sparingly soluble in a 1:10 solution of ethanol:PBS, pH 7.2.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least one year after receipt when stored at -20°C. We do not recommend storing the aqueous solution for more than one day.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

A bacterial genotoxin reveals a p53-proteasome-LC3 regulatory axis that drives the suppression of autophagy in cells experiencing sublethal DNA damage: Lieu, D. J., Crowder, M. K., et al.; iScience 28, 112118 (2025), Abstract
TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma: Brown, J. A., Yonekubo, Y., et al.; Cell Stem Cell 21, 650 (2017), Abstract
Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation: M. Charni, et al.; Cell Death Differ. 23, 509 (2016), Application(s): Cell Culture, Abstract
A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins: J. Soares, et al.; Pharmacol. Res. 95, 42 (2015), Application(s): Cell Culture, Abstract
Whole-genome cartography of p53 response elements ranked on transactivation potential: T. Tebaldi, et al.; BMC Genomics 16, 464 (2015), Application(s): Cell Culture, Abstract — Full Text
A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity: B. Wawrzynow, et al.; J. Biol. Chem. 284, 11517 (2009), Abstract
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas: G. Sarek, et al.; J. Clin. Invest. 117, 1019 (2007), Abstract — Full Text
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2: L.T. Vassilev, et al.; Science 303, 844 (2004), Abstract

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