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NU2058

ALX-270-394

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CDK inhibitor

Competitive inhibitor of CDK1/cyclin B (IC₅₀=5µM) and CDK2/cyclin A (IC₅₀=12µM). Pharmacologically distinct from the relative specific inhibitor of CDK1/2 roscovitine (Prod. No. BML-CC205).

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Product Details

Alternative Name	O6-Cyclohexylmethylguanine
CAS	161058-83-9
Couple Target	CDK
Couple Type	Inhibitor
Formula	C₁₂H₁₇N₅O
MW	247.3
Solubility	Soluble in water or DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2: L.R. Harrison, et al.; Biochem. Pharmacol. 77, 1586 (2009), Abstract
The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death: M. Ferguson, et al.; Cell Cycle 3, 80 (2004), Abstract
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles: C.E. Arris, et al.; J. Med. Chem. 43, 2797 (2000), Abstract

Related Products

(R)-Roscovitine

BML-CC205

CDK inhibitor

22 citations

Alternative Name	6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine, 2(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Seliciclib
CAS	186692-46-6
Couple Type	Inhibitor
Purity	≥95% (HPLC, TLC)

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NU2058

ALX-270-394

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