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NS-2028

ALX-270-210

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Guanylyl cyclase inhibitor

A potent and selective, cell-permeable inhibitor of nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC). Inhibition is irreversible. Inhibits also the basal, the YC-1 and the coenhanced sGC activity. Complete inhibition of NO-induced relaxation in vascular and nonvascular smooth muscle at 1μM.

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Product Details

Alternative Name	4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
Appearance	White to off-white crystalline powder.
CAS	204326-43-2
Couple Target	Guanylyl cyclase
Couple Type	Inhibitor
Formula	C₉H₅BrN₂O₃
MW	269.1
Purity	≥98% (TLC)
Solubility	Soluble in DMSO or 100% ethanol; insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

S-nitrosoglutathione induces ciliary neurotrophic factor expression in astrocytes, which has implications to protect the central nervous system under pathological conditions: Paintlia, M. K., Paintlia, A. S., et al.; J. Biol. Chem. 288, 3831 (2013), Abstract
Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology: Capuano, A., De Corato, A., et al.; Mol. Pain 5, 43 (2009), Abstract
Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase: I. Fleming, et al.; PNAS 96, 1123 (1999), Abstract
Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production: L. Bang, et al.; Scand. Cardiovasc. J. 33, 33 (1999), Abstract
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase: S.P. Olesen, et al.; Br. J. Pharmacol. 123, 299 (1998), Abstract

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NS-2028

ALX-270-210

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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