NS-1643

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K⁺ channel activator

A novel and selective HERG K⁺ channel activator (EC₅₀=10.5 µM). Activates ERG2 channels. Displays antiarrhythmic properties in rabbit models.

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Alternative Name	N,N’-Bis[2-hydroxy-5-(trifluoromethyl)phenyl] urea
Appearance	White solid
CAS	448895-37-2
Couple Target	Potassium channel
Couple Type	Activator
Formula	C₁₅H₁₀F₆N₂O₃
MW	380.2
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or ethanol (25mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome: T.G. Diness, et al.; Cardiovasc. Res. 79, 61 (2008), Abstract
Activation of ERG2 potassium channels by the diphenylurea NS1643: P. Elmedyb, et al.; Neuropharmacology 53, 283 (2007), Abstract
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643): R.S. Hansen, et al.; Mol. Pharmacol. 69, 266 (2006), Abstract

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