NPPB

BML-CM100

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Cl^– channel blocker

A potent chloride channel blocker (IC₅₀=0.1-100 µM depending on channel subtype and assay method). Inhibits cyclooxygenase (COX; IC₅₀=8 µM). Evidence of mitochondrial uncoupling in mouse peritoneal macrophages, due to protonophore activity.

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Product Details

Alternative Name	5-Nitro-2-(3’-phenylpropyl-amino)benzoic acid
Appearance	Yellow solid.
CAS	107254-86-4
Couple Target	Chloride channel, COX
Couple Type	Blocker, Inhibitor
Formula	C₁₆H₁₆N₂O₄
MW	300.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml; warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The adenosine A2B receptor is involved in anion secretion in human pancreatic duct Capan-1 epithelial cells: M. Hayashi, et al.; Pflugers Arch. 468, 1171 (2016), Application(s): Cell culture, Abstract — Full Text
Inhibition of Regulatory Volume Decrease Enhances the Cytocidal Effect of Hypotonic Shock in Hepatocellular Carcinoma: M. Kudou, et al.; J. Cancer 7, 1524 (2016), Application(s): Cell culture, human HCC cell lines, Abstract — Full Text
Effects of NPPB (5-nitro-2-(3-phenylpropylamino)benzoic acid) on chloride transport in intestinal tissues and the T84 cell line: D.J. Keeling, et al.; Biochim. Biophys. Acta 1115, 42 (1991), Abstract
Different types of blockers of the intermediate-conductance outwardly rectifying chloride channel in epithelia: M. Tilmann, et al.; Pflugers Arch. 418, 556 (1991), Abstract
Inhibition of prostaglandin E2 synthesis by a blocker of epithelial chloride channels: W. Breuer & K.L. Skorecki; Biochem. Biophys. Res. Commun. 163, 398 (1989), Abstract
Actions of the Cl- channel blocker NPPB on absorptive and secretory transport processes of Na+ and Cl- in rat descending colon: M. Diener & W. Rummel; Acta Physiol. Scand. 137, 215 (1989), Abstract
Cl(-)-channel blockers in the thick ascending limb of the loop of Henle. Structure activity relationship: P. Wangemann, et al.; Pflugers Arch. 407, S128 (1986), Abstract

Last modified: May 29, 2024

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NPPB

BML-CM100

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