Home Shop NPC-15437 . dihydrochloride

NPC-15437 . dihydrochloride

ALX-270-104

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PKC inhibitor

Selective inhibitor of protein kinase C (PKC).

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Product Details

Alternative Name	(S)-2,6-diamino-N-{[1′-(1”-oxotridecyl)-2′-piperidinyl]methyl}hexanamide . 2HCl
Appearance	White to off-white solid.
CAS	136449-85-9; 141774-20-1
Couple Target	PKC
Couple Type	Inhibitor
Formula	C₂₅H₅₀N₄O₂ . 2 HCl
MW	511.6
Purity	≥98% (HPLC)
Solubility	Soluble in water, DMSO or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Spinal atypical protein kinase C activity is necessary to stabilize inactivity-induced phrenic motor facilitation: Strey, K. A., Nichols, N. L., et al.; J. Neurosci. 32, 16510 (2012), Abstract
2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain: J.P. Sullivan, et al.; Mol. Pharmacol. 41, 38 (1992), Abstract
2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C: J.P. Sullivan, et al.; Agents Actions 34, 142 (1991), Abstract
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs: J.P. Sullivan, et al.; FEBS Lett. 285, 120 (1991), Abstract

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