Nonactin

ALX-450-008

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Monovalent cation ionophore

Macrotetrolide antibiotic. Monovalent cation ionophore with high selectivity for ammonium and potassium. Specifically inhibits the processing of cytoplasmic precursor proteins destined for the mitochondria. Inhibits the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in multidrug resistant (MDR) cancer cells.

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Product Details

Alternative Name	Polynactin, Werramycin A
Appearance	White to off-white crystalline solid.
CAS	6833-84-7
Formula	C₄₀H₆₄O₁₂
MI	14: 6675
MW	736.9
Purity	≥98% (TLC) (Total homologs)
Purity Detail	Mixture of two homologs (~80% nonactin and ~20% monactin)
RTECS	RH1685000
Solubility	Soluble in DMSO (10mg/ml), dichloromethane (10mg/ml), methanol, 100% ethanol; insoluble in water.
Source	Isolated from Streptomyces griseus.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A new potentiometric ammonium electrode for biosensor construction: E. Karakus, et al.; Artif. Cells. Blood Substit. Immobil. Biotechnol. 34, 523 (2006), Abstract
Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane: C.A. Garcia, et al.; J. Pharm. Biomed. Anal. 31, 11 (2003), Abstract
Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effects of ionophores on 4’-O-tetrahydropyranyl-adriamycin incorporation in K562 drug-resistant cells: M.N. Borrel, et al.; Eur. J. Biochem. 223, 125 (1994), Abstract
Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin: S.N. Graven, et al.; Biochemistry 5, 1735 (1966), Abstract
Antibiotics as tools for metabolic studies. V. Effect of nonactin, monactin, dinactin, and trinactin on oxidative phosphorylation and adenosine triphosphatase induction: S.N. Graven, et al.; Biochemistry 5, 1729 (1966), Abstract
The in vitro activity of nonactin and Its homologs: Monactin, dinactin and trinactin: E. Meyers, et al.; J. Antibiot. 18, 128 (1965), Abstract
[Antibacterial spectrum of nonactin with special consideration of Corynebacteriaceae]: W. Kohler, et al.; Zentralbl Bakteriol [Orig] 194, 457 (1964), Abstract

Related Products

Trinactin

ALX-380-238

Cation ionophore

3 citations

Alternative Name	Antibiotic AKD 1D, Antibiotic S 3466B
CAS	7561-71-9
Purity	≥95% (HPLC)

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Nonactin

ALX-450-008

Product Details

Handling & Storage

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