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Noladin ether

BML-FA033

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Cannabinoid receptor ligand

Endogenous cannabinoid agonist isolated from porcine brain. Binds specifically to CB₁ (K_i=21.2nM) and CB₂ (K_i=>3µM) receptors. Causes sedation hypothermia, intestinal immobility and mild antinociception in mice. Chemically stable, but less potent than 2-arachidonoylglycerol (Prod. No. BML-FA028) with an endogenous half-life time of hours rather than minutes.

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Product Details

Alternative Name	2-Arachidonyl glyceryl ether, 2-AG ether, 5Z,8Z,11Z,14Z-Eicosatetraen-2-glyceryl ether
Appearance	Yellow oil.
CAS	222723-55-9
Couple Target	Cannabinoid receptor
Couple Type	Ligand
Formula	C₂₃H₄₀O₃
MW	364.6
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (40mg/ml) or ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C when stored under an atmosphere of argon or nitrogen.
Handling	Protect from oxygen. Keep under inert gas.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice: Y. Avraham, et al.; Brain Res. Bull. 65, 117 (2005), Abstract
The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors: J.L. Shoemaker, et al.; J. Pharmacol. Exp. Ther. 314, 868 (2005), Abstract
Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors: J.L. Shoemaker, et al.; J. Pharmacol. Exp. Ther. 315, 828 (2005), Abstract
Further advances in the synthesis of endocannabinoid-related ligands: A. Mahadevan and R.K. Razdan; AAPS J. 7, E496 (2005), Abstract — Full Text
2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion: K. Nithipatikom, et al.; Cancer Res. 64, 8826 (2004), Abstract — Full Text
Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 G(i/o) linked receptor: M. Duncan, et al.; Br. J. Pharmacol. 142, 509 (2004), Abstract — Full Text
Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors: G. Appendino, et al.; Bioorg. Med. Chem. Lett. 13, 43 (2003), Abstract
Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid: K. Laine, et al.; Invest. Ophthalmol. Vis. Sci. 43, 3216 (2002), Abstract
Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues: F. Fezza, et al.; FEBS Lett. 513, 294 (2002), Abstract
2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor: L. Hanus, et al.; PNAS 98, 3662 (2001), Abstract

Last modified: May 29, 2024

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Noladin ether

BML-FA033

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