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Nocodazole

BML-T101

11 citations

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Microtubule inhibitor

Synthetic reversible microtubule inhibitor.

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Product Details

Alternative Name	Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate, R 17934
Appearance	Solid. White, off-white, orange and possibly even a brown/pink color.
CAS	31430-18-9
Couple Target	Microtubule
Couple Type	Inhibitor
Formula	C₁₄H₁₁N₃O₃S
MW	301.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (10mg/ml) or dimethyl formamide; almost insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Apical PAR protein caps orient the mitotic spindle in C. elegans early embryos: Stolpner, N. J., Manzi, N. I., et al.; Curr. Biol. 33, 4312 (2023), Abstract
The Budding Yeast Ubiquitin Protease Ubp7 is a Novel Component Involved in S-phase Progression: S. Bohm, et al.; J. Biol. Chem. 291, 4442 (2016), Application(s): Cell culture, Abstract — Full Text
NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions: Seldin, L., Poulson, N. D., et al.; Mol. Biol. Cell 24, 3651 (2013), Abstract
Kinesin molecular motor Eg5 functions during polypeptide synthesis: Bartoli, K. M., Jakovljevic, J., et al.; Mol. Biol. Cell 22, 3420 (2011), Abstract
Possible involvement of microtubules in platelet-activating factor-induced increases in microvascular permeability in vitro: A.M Northover & B.J. Northover; Inflammation 17, 633 (1993), Abstract
Role of microtubules in transferrin receptor transport from the cell surface to endosomes and the Golgi complex: M. Jin & M.D. Snider; J. Biol. Chem. 268, 18390 (1993), Abstract
Epithelial sphingolipid sorting is insensitive to reorganization of the Golgi by nocodazole, but is abolished by monensin in MDCK cells and by brefeldin A in Caco-2 cells: G. van Meer & W. van ‘t Hof; J. Cell Sci. 104, 833 (1993), Abstract
The effects of methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl) carbamate, (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro: M.J. De Brabander, et al.; Cancer Res. 36, 905 (1976), Abstract
Interaction of oncodazole (R 17934), a new antitumoral drug, with rat brain tubulin: J. Hoebeke, et al.; BBRC 69, 319 (1976), Abstract
R17934-NSC238159: a new antitumor drug–II. Effect on mitotic cycle of L1210 leukemia cells in vivo and synergism with cytosine arabinoside (NSC63878): G. Atassi, et al.; Eur. J. Cancer 11, 609 (1975), Abstract

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Nocodazole

BML-T101

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